Assessment of nucleolar organizer regions (Ag-NORs) in bronchial dysplasia and roentgenographically occult bronchogenic squamous cell carcinoma

K. Usuda, Y. Saito, G. Okaniwa, T. Sakuma, M. Handa, A. Sakurada, C. Endo, M. Sato, N. Nagamoto, S. Fujimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mean argyrophil nucleolar organizer regions (Ag-NORs) per nucleus were determined on columnar epithelium, bronchial dysplasia, roentgenographically occult squamous cell carcinoma and squamous cell carcinoma with roentgenographically findings in 76 formalin-fixed, paraffin-embedded resected specimens. 1) Mean Ag-NOR counts per nucleus (mean +/- standard deviation) were 1.67 +/- 0.30 in 10 columnar epitheliums, 2.74 +/- 0.41 in 13 lesions with bronchial dysplasia, 3.75 +/- 0.59 in 57 lesions with roentgenographically occult squamous cell carcinoma and 4.44 +/- 0.51 in 14 lesions with squamous cell carcinoma with roentgenographically findings. There were significant differences between each two groups. 2) In lesions with squamous call carcinoma, mean Ag-NOR counts per nucleus of T2, T3 or T4 tumor were significantly higher than those of T1 tumor. Mean Ag-NOR counts per nucleus of N1 or N2 tumor were significantly higher than those of N0 tumor.

Original languageEnglish
Pages (from-to)836-840
Number of pages5
Journal[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai
Volume43
Issue number6
Publication statusPublished - 1995 Jun

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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