Assessment of mental deterioration with the Cognitive Abilities Screening Instrument (CASI) and glucose hypometabolism in Alzheimer's disease: The Osaki-Tajiri Project

S. Yamaguchi, K. Meguro, H. Ishii, M. Meguro, K. Akanuma

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The Cognitive Abilities Screening Instrument (CASI) is a screening test for dementia consisting of 9 domains. We investigated the relationships between CASI domain scores and cerebral glucose metabolism (CMRglc) as shown by positron emission tomography. Fifteen patients with very mild Alzheimer's disease (AD) and 15 with mild AD were studied using the [18F]fluoro-deoxyglucose method. The 9 CASI domains were classified into four clusters (recent memory, frontal cortex cluster, posterior cortex cluster, and orientation). Using the region of interest method, the recent memory cluster was correlated with the bilateral hippocampal CMRglc, the frontal cortex cluster was correlated with the bilateral anterior and right inferior frontal CMRglc, the posterior cortex cluster was correlated with the bilateral temporo-parieto-occipital and occipital CMRglc, and the orientation cluster was correlated with the left anterior frontal CMRglc (Spearman's correlations). The use of statistical parametric mapping showed that most CASI domains were correlated with CMRglc of the left frontal lobe, the temporal lobe, and the angular gyrus. These findings show that the mental dysfunction assessed using CASI in AD patients has a neurobiological basis.

Original languageEnglish
Pages (from-to)1430-1434
Number of pages5
JournalJournal of Clinical Neuroscience
Volume16
Issue number11
DOIs
Publication statusPublished - 2009 Nov

Keywords

  • Alzheimer's disease
  • Cognitive Abilities Screening Instrument
  • Fluoro-deoxyglucose
  • Positron emission tomography

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Assessment of mental deterioration with the Cognitive Abilities Screening Instrument (CASI) and glucose hypometabolism in Alzheimer's disease: The Osaki-Tajiri Project'. Together they form a unique fingerprint.

Cite this