Aspects of the preparation of 18F-2-deoxy-2-fluoro-D-glucose (18FDG) for medical use.

T. Irie, T. Ido, K. Fukushi, R. Iwata, M. Uoji, K. Tamate, T. Yamasaki, Y. Kashida

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Fluorine-18-2-deoxy-2-fluoro-D-glucose (18FDG) for medical use had been prepared with the attention regarding radiochemical yield and purity, specific activity and quality control. More than four 18F-by-products in 18F-adducts from the reaction of triacetyl glucal with 18F2 were detected by the autoradiography of thin layer plates in which two by-products could not be perfectly removed by a column chromatography, and selective collection of the eluate gave 18FDG with the purity of 96.7% as an average in 12 runs. At end of synthesis (EOS) 259-925 MB (7-25 mCi) of a sterilized, isotonic solution of 18FDG was obtained with the specific activity of 629-851 MBq (17-23 mCi)/mg at end of bombardment (EOB) after preparation time of 3-3.5 hr, in which bacteria and pyrogen were not detected.

    Original languageEnglish
    Pages (from-to)11-15
    Number of pages5
    JournalRadioisotopes
    Volume31
    Issue number1
    DOIs
    Publication statusPublished - 1982 Jan

    ASJC Scopus subject areas

    • Radiation

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