ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds

Nao Osaka, Takumi Takahashi, Shiori Murakami, Atsushi Matsuzawa, Takuya Noguchi, Takeshi Fujiwara, Hiroyuki Aburatani, Keiji Moriyama, Kohsuke Takeda, Hidenori Ichijo

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein 3- kinase family that activates both c-Jun NH 2-terminal kinase and p38 pathways in response to inflammatory cytokines and physicochemical stress. We report that ASK1 deficiency in mice results in dramatic retardation of wounding-induced hair regrowth in skin. Oligonucleotide microarray analysis revealed that expression of several chemotactic and activating factors for macrophages, as well as several macrophage-specific marker genes, was reduced in the skin wound area of ASK1-deficient mice. Intracutaneous transplantation of cytokine-activated bone marrow-derived macrophages strongly induced hair growth in both wild-type and ASK1-deficient mice. These findings indicate that ASK1 is required for wounding-induced infiltration and activation of macrophages, which play central roles in inflammation-dependent hair regrowth in skin.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalJournal of Cell Biology
Volume176
Issue number7
DOIs
Publication statusPublished - 2007 Mar 26

ASJC Scopus subject areas

  • Cell Biology

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