Artificial oligonucleotides consisting of an analog of nucleoside antibiotics, carbocyclic oxetanocins1

Nobuya Katagiri, Yoshihiro Morishita, Iichiro Oosawa, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Modified oligonucleotides, hexadecamers, containing carbocyclic analogues of oxetanocin A and T, have been synthesized from the corresponding chiral carbocyclic nucleosides. The oligonucleotide derived from carbocyclic oxetanocin A forms a stable triple-helix with uridine oligoribonucleotide even under physiological conditions.

Original languageEnglish
Pages (from-to)6835-6840
Number of pages6
JournalTetrahedron Letters
Volume40
Issue number37
DOIs
Publication statusPublished - 1999 Sep 10

Keywords

  • Artificial oligonucleotides
  • Carbocyclic oxetanocin
  • RNA
  • Triple-helix

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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