TY - JOUR
T1 - Artificial myocardium with an artificial baroreflex system using nano technology
AU - Yambe, Tomoyuki
AU - Shiraishi, Yasuyuki
AU - Yoshizawa, Makoto
AU - Tanaka, Akira
AU - Abe, Ken Ichi
AU - Sato, Fumihiro
AU - Matsuki, Hidetoshi
AU - Esashi, Masayoshi
AU - Haga, Yoichi
AU - Maruyama, Shigenao
AU - Takagi, Toshiyuki
AU - Luo, Yun
AU - Okamoto, Eiji
AU - Kubo, Yutaka
AU - Osaka, Motohisa
AU - Nanka, Shunsuke
AU - Saijo, Yoshifumi
AU - Mibiki, Yoshiaki
AU - Yamaguchi, Tasuku
AU - Shibata, Mune Ichi
AU - Nitta, Shinichi
N1 - Funding Information:
This paper was presented in part at the Third International Symposium on Chronobiology held at Sankei Hall, Tokyo, Japan. The authors would like to thank Mr. Kimio Kikuchi for experimental preparation and kind cooperation, Miss Yoko Ito and Mrs. Hisako Iijima for their excellent technical assistance and kind cooperation. This work was partly supported by a Grant in aid for scientific research (11480253), Research Grant for Cardiovascular Diseases from the Ministry of Health and Welfare and Program for Promotion of Fundamental Studies in Health Science in Organizing for Drug ADR Relief, R&D Promotion and Product Review of Japan.
PY - 2003/10
Y1 - 2003/10
N2 - Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the heart. At Tohoku University, development research of "the artificial myocardium" has been conducted, using a ball screw type electromagnetic motor. Furthermore, super-miniaturization is being attempted at present. Thus, a system with shape memory alloy is being developed. The cooling speed problem was solved by the application of the Peltier element. A drive at a speed equal to that of a heartbeat was realized by the application of this system. At present, a ventricular assist device is used for patients waiting for a heart transplant in Japan. An air driven type system disturbs a patient's QOL remarkably because it is connected to the drive device. With our concept, energy is provided by using the electromagnetic force from outside of the body by the use of transcutaneous energy transmission system. Magnetic shielding by amorphous fibers was used at Tohoku University to improve the total efficiency. A natural heart can alter the cardiac output corresponding to the demand. Artificial internal organs must participate in the system of the living body, too. Tohoku University has developed a resistance based artificial heart control algorithm, which simulated a baroreflex system to cope with every demand. Nano level sensing equipment is now under development at Tohoku University. At present, development is being conducted aiming at an "intelligent artificial myocardium".
AB - Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the heart. At Tohoku University, development research of "the artificial myocardium" has been conducted, using a ball screw type electromagnetic motor. Furthermore, super-miniaturization is being attempted at present. Thus, a system with shape memory alloy is being developed. The cooling speed problem was solved by the application of the Peltier element. A drive at a speed equal to that of a heartbeat was realized by the application of this system. At present, a ventricular assist device is used for patients waiting for a heart transplant in Japan. An air driven type system disturbs a patient's QOL remarkably because it is connected to the drive device. With our concept, energy is provided by using the electromagnetic force from outside of the body by the use of transcutaneous energy transmission system. Magnetic shielding by amorphous fibers was used at Tohoku University to improve the total efficiency. A natural heart can alter the cardiac output corresponding to the demand. Artificial internal organs must participate in the system of the living body, too. Tohoku University has developed a resistance based artificial heart control algorithm, which simulated a baroreflex system to cope with every demand. Nano level sensing equipment is now under development at Tohoku University. At present, development is being conducted aiming at an "intelligent artificial myocardium".
KW - Artificial baroreflex
KW - Intelligent artificial myocardium
KW - Nano technology
KW - Shape memory alloy
KW - Transcutaneous energy transmission
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U2 - 10.1016/j.biopha.2003.08.016
DO - 10.1016/j.biopha.2003.08.016
M3 - Article
C2 - 14572688
AN - SCOPUS:0142231363
VL - 57
SP - 122
EP - 125
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - SUPPL. 1
ER -