Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Tohru Oishi; Keiichi Konoki; Rie Tamate; Kohei Torikai; Futoshi Hasegawa; Nobuaki Matsumori; Michio Murata

doi:10.1016/j.bmcl.2012.04.053

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca ²⁺ influx in rat glioma C6 cells

Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai, Futoshi Hasegawa, Nobuaki Matsumori, Michio Murata

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca²⁺ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca²⁺ influx that has ever been reported.

Original language	English
Pages (from-to)	3619-3622
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.053
Publication status	Published - 2012 Jun 1

Keywords

Artificial ladder-shaped polyether
Calcium ion
Inhibitor
Maitotoxin
Natural product

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2012.04.053

Cite this

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca ²⁺ influx in rat glioma C6 cells. / Oishi, Tohru; Konoki, Keiichi; Tamate, Rie; Torikai, Kohei; Hasegawa, Futoshi; Matsumori, Nobuaki; Murata, Michio.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 11, 01.06.2012, p. 3619-3622.

Research output: Contribution to journal › Article › peer-review

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note = "Funding Information: This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.",

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AU - Hasegawa, Futoshi

AU - Matsumori, Nobuaki

AU - Murata, Michio

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