Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Tohru Oishi; Keiichi Konoki; Rie Tamate; Kohei Torikai; Futoshi Hasegawa; Nobuaki Matsumori; Michio Murata

doi:10.1016/j.bmcl.2012.04.053

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca ²⁺ influx in rat glioma C6 cells

Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai, Futoshi Hasegawa, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca²⁺ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca²⁺ influx that has ever been reported.

Original language	English
Pages (from-to)	3619-3622
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.053
Publication status	Published - 2012 Jun 1

Keywords

Artificial ladder-shaped polyether
Calcium ion
Inhibitor
Maitotoxin
Natural product

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2012.04.053

Cite this

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title = "Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells",

abstract = "Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.",

keywords = "Artificial ladder-shaped polyether, Calcium ion, Inhibitor, Maitotoxin, Natural product",

author = "Tohru Oishi and Keiichi Konoki and Rie Tamate and Kohei Torikai and Futoshi Hasegawa and Nobuaki Matsumori and Michio Murata",

note = "Funding Information: This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.",

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T1 - Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

AU - Oishi, Tohru

AU - Konoki, Keiichi

AU - Tamate, Rie

AU - Torikai, Kohei

AU - Hasegawa, Futoshi

AU - Matsumori, Nobuaki

AU - Murata, Michio

N1 - Funding Information: This work was supported by The Uehara Memorial Foundation, a Grant-in-Aid for Scientific Research (B) (No. 21350028) from JSPS, and a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106530) from MEXT.

PY - 2012/6/1

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N2 - Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

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KW - Maitotoxin

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