Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai, Futoshi Hasegawa, Nobuaki Matsumori, Michio Murata

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

    Original languageEnglish
    Pages (from-to)3619-3622
    Number of pages4
    JournalBioorganic and Medicinal Chemistry Letters
    Volume22
    Issue number11
    DOIs
    Publication statusPublished - 2012 Jun 1

    Keywords

    • Artificial ladder-shaped polyether
    • Calcium ion
    • Inhibitor
    • Maitotoxin
    • Natural product

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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