Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai, Futoshi Hasegawa, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

Original languageEnglish
Pages (from-to)3619-3622
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number11
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • Artificial ladder-shaped polyether
  • Calcium ion
  • Inhibitor
  • Maitotoxin
  • Natural product

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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