Arterial lactate level in neurosurgical patients

R. Saito, K. Sato, M. Kato, T. Yoshimoto

Research output: Contribution to journalArticlepeer-review


Lactate is known to accumulate when systemic circulation is insufficient. We assessed the state of systemic circulation from this point of view in 154 neurosurgical cases. Among these cases 54 subjects had ruptured aneurysms, and 100 had other conditions. After the induction of general anesthesia, blood lactate levels were assessed from arterial blood. In some cases, jugular blood was also sampled simultaneously. There was no difference between lactate in arterial and in jugular blood. Arterial lactate levels tended to be higher in cases with ruptured aneurysms (2.5±1.5mmol/l; mean±S.D.) and with intracerebral hemorrhage (2.0±1.2mmol/l). Arterial lactate in patients with ruptured aneurysms was statistically higher than that in cases with unruptured aneurysms (p<0.05), brain tumor (p<0.05), and spinal diseases (p<0.01). The arterial lactate in cases of emergent operation (2.3±1.4mmol/l) was higher than that of scheduled operation (1.3±0.6mmol/l) (p<0.01). In cages of subarachnoid hemorrhage, arterial lactate was higher in cases operated on within 24 hours (2.9 ± 1.4 mmol/l) than cases operated on later (2.2±1.1mmol/l), although the difference was not statistically significant (p=0.05). No correlation was found between arterial lactate levels and Hunt and Kosnik grade (rs=0.228). These results suggest that in neurosurgically emergent patients, especially those with ruptured aneurysm, there will be some unbalance between systemic oxygen supply and demand.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJapanese Journal of Neurosurgery
Issue number1
Publication statusPublished - 2000
Externally publishedYes


  • Catecholamine
  • Lactate
  • Subarachnoid hemorrhage
  • Sympathetic storm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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