Aromatic polyketide production in cordyceps indigotica, an entomopathogenic fungus, induced by exposure to a histone deacetylase inhibitor

Teigo Asai, Takashi Yamamoto, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Cultivation of Cordyceps indigotica, an entomopathogenic fungus, in the presence of suberoyl bis-hydroxamic acid (an HDAC inhibitor) greatly activated its polyketide synthesis apparatus to afford six novel aromatic polyketides, indigotides C-F (1-4), 13-hydroxyindigotide A (5), and 8-O-methylindigotide B (6). The structures of these compounds were determined by NMR spectroscopic analyses. Among the compounds, indigotides C-E (1-3) possessed unprecedented dimeric polyketide frameworks possibly generated via a [4 + 2] cycloaddition or Michael type reaction.

Original languageEnglish
Pages (from-to)2006-2009
Number of pages4
JournalOrganic letters
Volume14
Issue number8
DOIs
Publication statusPublished - 2012 Apr 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Aromatic polyketide production in cordyceps indigotica, an entomopathogenic fungus, induced by exposure to a histone deacetylase inhibitor'. Together they form a unique fingerprint.

Cite this