Aromatic polyketide glycosides from an entomopathogenic fungus, Cordyceps indigotica

Teigo Asai, Takashi Yamamoto, Yu Ming Chung, Fang Rong Chang, Yang Chang Wu, Kouwa Yamashita, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A new aromatic polyketide glycoside, indigotide A (1), was isolated from the culture broth of the entomopathogenic fungus, Cordyceps indigotica, along with known cyclic depsipeptides, destruxins A, A 2, B, B 2 and E (3-7), and a polyketide, NG-393 (8). Repeated treatment of the C. indigotica culture broth with 5-azacytidine, a DNA methyltransferase inhibitor, led to the isolation of another new aromatic polyketide glycoside, indigotide B (2).

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number3
DOIs
Publication statusPublished - 2012 Jan 18

Keywords

  • DNA methyltransferase inhibitor
  • Entomopathogenic fungi
  • Epigenetics
  • Polyketides
  • Secondary metabolites

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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