Architecture of odor information processing in the olfactory system

Takaaki Sato, Junzo Hirono, Hiroshi Hamana, Takahiro Ishikawa, Akira Shimizu, Ichiro Takashima, Riichi Kajiwara, Toshio Iijima

    Research output: Contribution to journalReview articlepeer-review

    17 Citations (Scopus)

    Abstract

    Since the discovery of the superfamily of approximately 1000 odorant receptor genes in rodents, the structural simplicity as well as the complexity of the olfactory system have been revealed. The simple aspects include the one neuron-one receptor rule and the exclusive convergence of projections from receptor neurons expressing the same receptors to one or two glomeruli in the olfactory bulb. Odor decoding in the olfactory cortex or higher cortical areas is likely to be a complicated process that depends on the sequence of signal activation and the relative signal intensities of receptors overlapping for similar but different odors. The aim of the present study was to investigate odor information processing both in receptors and in the olfactory cortex. At the receptor level, the similarity and difference in receptor codes between a pair of chiral odorants were examined using the tissue-printing method for sampling all the epithelial zones. In order to dissect odor-driven signal processing in the olfactory cortex by reducing cross-talk with the non-olfactory activities, such as cyclic respiration or other sensory inputs, an in vitro preparation of isolated whole brain with an attached nose was developed, and the methodologies and resulting hypothesis of receptor-sensitivitydependent hierarchical odor information coding were reviewed.

    Original languageEnglish
    Pages (from-to)195-206
    Number of pages12
    JournalAnatomical Science International
    Volume83
    Issue number4
    DOIs
    Publication statusPublished - 2008

    Keywords

    • Odor coding
    • Odor discrimination
    • Olfaction
    • Piriform cortex
    • Sensory information processing

    ASJC Scopus subject areas

    • Anatomy

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