Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation

Research output: Contribution to journalShort surveypeer-review

45 Citations (Scopus)

Abstract

Upon antigen stimulation, B lymphoid cells undergo terminal differentiation into antibody-secreting plasma cells. This process accompanies drastic changes in cell functions such as a loss of B-cell identity, induction of secretory apparatus, and an extremely increased transcription of antibody genes. These changes are the result of re-wiring of a transcription factor network in B and plasma cells. While the transcription repressor Blimp-1 induces plasma cell differentiation, another repressor Bach2 has emerged as a negative regulator of Blimp-1 in B cells. These two transcription factors, together with other several factors, appear to constitute a main transcriptional regulatory network for the terminal differentiation process of plasma cells from B cells.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalJournal of biochemistry
Volume141
Issue number6
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Bach2
  • Blimp-1
  • Class switch recombination
  • Plasma cells
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation'. Together they form a unique fingerprint.

Cite this