Aquaporin-4 antibody-positive myelitis initially biopsied for suspected spinal cord tumors: Diagnostic considerations

Douglas Kazutoshi Sato, Tatsuro Misu, Cristiane Franklin Rocha, Dagoberto Callegaro, Ichiro Nakashima, Masashi Aoki, Kazuo Fujihara, Marco Aurelio Lana-Peixoto

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Two patients with longitudinally extensive myelopathy were initially biopsied for suspected spinal cord tumors. Both patients were later diagnosed with neuromyelitis optica spectrum disorders (NMOSD) supported by their AQP4-seropositivity. Pathological review of both biopsies revealed demyelinated lesions with thickened vessel walls and tissue rarefaction. Immunohistochemical staining demonstrated findings compatible with acute NMOSD lesions in one case while the other case exhibited findings consistent with chronic NMOSD lesions. A pre-biopsy differential diagnosis of longitudinally extensive spinal cord tumors should include NMOSD. Specific biopsy features, such as cystic changes with vascular wall thickening and astrocyte injury, should raise suspicion for NMOSD.

Original languageEnglish
Pages (from-to)621-626
Number of pages6
JournalMultiple Sclerosis Journal
Volume20
Issue number5
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • Neuromyelitis optica
  • aquaporin-4
  • biopsy
  • differential diagnosis
  • pathology
  • spinal cord tumor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Aquaporin-4 antibody-positive myelitis initially biopsied for suspected spinal cord tumors: Diagnostic considerations'. Together they form a unique fingerprint.

  • Cite this