Abstract
Japanese cedar (Cryptomeria japonica; CJ) pollinosis is a typical type I allergy induced by CJ pollen and one of the most common allergic diseases in Japan. New immunotherapies have been developed for treatment of CJ pollinosis. We focus here on new immunotherapies for CJ pollinosis including sublingual immunotherapy with crude extract of CJ antigen, oral immunotherapy with transgenic rice expressing CJ allergens, a peptide vaccine using T cell epitopes of CJ allergens, DNA vaccines encoding either the CJ allergen gene or T cell epitope gene, and adjuvant-conjugated vaccines using CJ allergen conjugated with adjuvants such as CpG oligodeoxynucleotide or pullulan.
Original language | English |
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Pages (from-to) | 431-438 |
Number of pages | 8 |
Journal | Auris Nasus Larynx |
Volume | 38 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 Aug |
Externally published | Yes |
Keywords
- Allergen
- CpG
- Immunotherapy
- Peptide
- Pollen
- Vaccine
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology