Approaches to immunotherapies for Japanese cedar pollinosis

Masahiro Sakaguchi, Kazuki Hirahara, Takashi Fujimura, Masako Toda

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Japanese cedar (Cryptomeria japonica; CJ) pollinosis is a typical type I allergy induced by CJ pollen and one of the most common allergic diseases in Japan. New immunotherapies have been developed for treatment of CJ pollinosis. We focus here on new immunotherapies for CJ pollinosis including sublingual immunotherapy with crude extract of CJ antigen, oral immunotherapy with transgenic rice expressing CJ allergens, a peptide vaccine using T cell epitopes of CJ allergens, DNA vaccines encoding either the CJ allergen gene or T cell epitope gene, and adjuvant-conjugated vaccines using CJ allergen conjugated with adjuvants such as CpG oligodeoxynucleotide or pullulan.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalAuris Nasus Larynx
Issue number4
Publication statusPublished - 2011 Aug
Externally publishedYes


  • Allergen
  • CpG
  • Immunotherapy
  • Peptide
  • Pollen
  • Vaccine

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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