Application of the chemical imaging sensor to electrophysiological measurement of a neural cell

Hiroshi Tanaka, Tatsuo Yoshinobu, Hiroshi Iwasaki

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The chemical imaging sensor is applied to electrophysiological measurement of a neural cell. In this method, neural cells are cultured directly on the sensing surface, and a laser beam is used to specify a cell to be measured. The amplitude of the ac photocurrent induced by the laser beam is measured to detect the change of the membrane potential of the cell. In this study, the membrane potential of the cell is varied by injection of a dc current, and it is demonstrated that the ac photocurrent signal responds to the membrane potential. This method would enable noninvasive electric measurement of neural cells, networks or tissues under long-term culture.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume59
Issue number1
DOIs
Publication statusPublished - 1999 Oct 5
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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