Application of optogenetics in epilepsy research

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epilepsy is a disease characterized by seizures arising from paroxysmal and self-limited hypersynchrony of neurons. However, the mechanism by which the normal brain develops epilepsy, which involves a chronic process of structural and morphological changes known as epileptogenesis, is not fully understood. Optogenetics involves the use of genetic engineering and optics to monitor or control nerve cell activity. Compared to classical electrophysiological experiments, the application of optogenetics in epilepsy research has many advantages because it allows selective photic stimulation of cell types and electrical observation without introducing artifacts.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages557-562
Number of pages6
DOIs
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1293
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Animal model
  • Benign and chronic disease
  • Epilepsy
  • Ethical issue
  • Seizure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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