Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing

Ramin Banan Sadeghian; Jiuhui Han; João Ribas; Amir Nasajpour; Margaux Duchamp; Seyed Ali Mousavi Shaegh; Serge Ostrovidov; Sahar Salehi; Mingwei Chen; Ali Khademhosseini

doi:10.1109/NANO.2016.7751411

Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing

Ramin Banan Sadeghian, Jiuhui Han, João Ribas, Amir Nasajpour, Margaux Duchamp, Seyed Ali Mousavi Shaegh, Serge Ostrovidov, Sahar Salehi, Mingwei Chen, Ali Khademhosseini

Creative Interdisciplinary Research Division

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set of highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) the NPG-based electrodes displayed a superoxide sensitivity of 0.24 nA nM-1 and a low-level of detection of 5 nM towards superoxide. The planar electrodes were then interfaced with HUVEC cells and were able to detect the release of extracellular superoxide upon stimulation with an endogenous superoxide producer. In addition, we studied the superoxide sensing performance of a three-dimensional (3D) macroporous mesh of gold decorated with NPG as a potential ultrasensitive superoxide biosensor.

Original language	English
Title of host publication	16th International Conference on Nanotechnology - IEEE NANO 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	19-21
Number of pages	3
ISBN (Electronic)	9781509039142
DOIs	https://doi.org/10.1109/NANO.2016.7751411
Publication status	Published - 2016 Nov 21
Event	16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan Duration: 2016 Aug 22 → 2016 Aug 25

Publication series

Name	16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other	16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Country/Territory	Japan
City	Sendai
Period	16/8/22 → 16/8/25

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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10.1109/NANO.2016.7751411

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Sadeghian, R. B., Han, J., Ribas, J., Nasajpour, A., Duchamp, M., Shaegh, S. A. M., Ostrovidov, S., Salehi, S., Chen, M., & Khademhosseini, A. (2016). Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing. In 16th International Conference on Nanotechnology - IEEE NANO 2016 (pp. 19-21). [7751411] (16th International Conference on Nanotechnology - IEEE NANO 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2016.7751411

Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing. / Sadeghian, Ramin Banan; Han, Jiuhui; Ribas, João et al.

16th International Conference on Nanotechnology - IEEE NANO 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 19-21 7751411 (16th International Conference on Nanotechnology - IEEE NANO 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sadeghian, RB, Han, J, Ribas, J, Nasajpour, A, Duchamp, M, Shaegh, SAM, Ostrovidov, S, Salehi, S, Chen, M & Khademhosseini, A 2016, Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing. in 16th International Conference on Nanotechnology - IEEE NANO 2016., 7751411, 16th International Conference on Nanotechnology - IEEE NANO 2016, Institute of Electrical and Electronics Engineers Inc., pp. 19-21, 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016, Sendai, Japan, 16/8/22. https://doi.org/10.1109/NANO.2016.7751411

Sadeghian RB, Han J, Ribas J, Nasajpour A, Duchamp M, Shaegh SAM et al. Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing. In 16th International Conference on Nanotechnology - IEEE NANO 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 19-21. 7751411. (16th International Conference on Nanotechnology - IEEE NANO 2016). doi: 10.1109/NANO.2016.7751411

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title = "Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing",

abstract = "We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set of highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) the NPG-based electrodes displayed a superoxide sensitivity of 0.24 nA nM-1 and a low-level of detection of 5 nM towards superoxide. The planar electrodes were then interfaced with HUVEC cells and were able to detect the release of extracellular superoxide upon stimulation with an endogenous superoxide producer. In addition, we studied the superoxide sensing performance of a three-dimensional (3D) macroporous mesh of gold decorated with NPG as a potential ultrasensitive superoxide biosensor.",

author = "Sadeghian, {Ramin Banan} and Jiuhui Han and Jo{\~a}o Ribas and Amir Nasajpour and Margaux Duchamp and Shaegh, {Seyed Ali Mousavi} and Serge Ostrovidov and Sahar Salehi and Mingwei Chen and Ali Khademhosseini",

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doi = "10.1109/NANO.2016.7751411",

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AU - Sadeghian, Ramin Banan

AU - Han, Jiuhui

AU - Ribas, João

AU - Nasajpour, Amir

AU - Duchamp, Margaux

AU - Shaegh, Seyed Ali Mousavi

AU - Ostrovidov, Serge

AU - Salehi, Sahar

AU - Chen, Mingwei

AU - Khademhosseini, Ali

PY - 2016/11/21

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N2 - We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set of highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) the NPG-based electrodes displayed a superoxide sensitivity of 0.24 nA nM-1 and a low-level of detection of 5 nM towards superoxide. The planar electrodes were then interfaced with HUVEC cells and were able to detect the release of extracellular superoxide upon stimulation with an endogenous superoxide producer. In addition, we studied the superoxide sensing performance of a three-dimensional (3D) macroporous mesh of gold decorated with NPG as a potential ultrasensitive superoxide biosensor.

AB - We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set of highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) the NPG-based electrodes displayed a superoxide sensitivity of 0.24 nA nM-1 and a low-level of detection of 5 nM towards superoxide. The planar electrodes were then interfaced with HUVEC cells and were able to detect the release of extracellular superoxide upon stimulation with an endogenous superoxide producer. In addition, we studied the superoxide sensing performance of a three-dimensional (3D) macroporous mesh of gold decorated with NPG as a potential ultrasensitive superoxide biosensor.

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Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing

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