Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing

Ramin Banan Sadeghian, Jiuhui Han, João Ribas, Amir Nasajpour, Margaux Duchamp, Seyed Ali Mousavi Shaegh, Serge Ostrovidov, Sahar Salehi, Mingwei Chen, Ali Khademhosseini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set of highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) the NPG-based electrodes displayed a superoxide sensitivity of 0.24 nA nM-1 and a low-level of detection of 5 nM towards superoxide. The planar electrodes were then interfaced with HUVEC cells and were able to detect the release of extracellular superoxide upon stimulation with an endogenous superoxide producer. In addition, we studied the superoxide sensing performance of a three-dimensional (3D) macroporous mesh of gold decorated with NPG as a potential ultrasensitive superoxide biosensor.

Original languageEnglish
Title of host publication16th International Conference on Nanotechnology - IEEE NANO 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages19-21
Number of pages3
ISBN (Electronic)9781509039142
DOIs
Publication statusPublished - 2016 Nov 21
Event16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan
Duration: 2016 Aug 222016 Aug 25

Publication series

Name16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
CountryJapan
CitySendai
Period16/8/2216/8/25

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Application of nanoporous gold in planar and mesh forms in electrochemical superoxide biosensing'. Together they form a unique fingerprint.

Cite this