Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones

Yujiro Hayashi; Koichi Nishimura

doi:10.1246/cl.2002.296

Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones

Yujiro Hayashi, Koichi Nishimura

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO₄. Only a moderate yield was obtained under atmospheric pressure.

Original language	English
Pages (from-to)	296-297
Number of pages	2
Journal	Chemistry Letters
Issue number	3
DOIs	https://doi.org/10.1246/cl.2002.296
Publication status	Published - 2002 Mar 5
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2002.296

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title = "Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones",

abstract = "High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.",

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doi = "10.1246/cl.2002.296",

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AU - Nishimura, Koichi

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N2 - High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.

AB - High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.

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Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones

Abstract

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