Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones

Yujiro Hayashi, Koichi Nishimura

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.

Original languageEnglish
Pages (from-to)296-297
Number of pages2
JournalChemistry Letters
Issue number3
DOIs
Publication statusPublished - 2002 Mar 5
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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