Application of high-intensity focused ultrasound for umbilical artery occlusion in a rabbit model

K. Ichizuka, S. Ando, M. Ichihara, T. Ishikawa, N. Uchiyama, K. Sasaki, S. Umemura, R. Matsuoka, A. Sekizawa, T. Okai, T. Akabane, M. Kushima

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Objectives: To investigate the application of high-intensity focused ultrasound (HIFU) for fetal umbilical artery blood flow occlusion in a rabbit model. Methods: A prototype HIFU transducer in combination with an imaging probe with Doppler capability was constructed. Using this transducer, HIFU was applied at 1.4, 2.75 or 5.5 kW/cm2 through the maternal abdominal skin to the fetal intra-abdominal umbilical arteries of four time-mated Japanese White rabbits (11 fetuses) on gestational day 25. Courses of 5-s HIFU exposure were performed until cessation of umbilical blood flow and cardiac arrest were confirmed by Doppler ultrasonography. Fetal necropsy was performed and exposed lesions were assessed by microscopic histological analysis. Results: The mean diameter of the fetal umbilical artery was 0.6 ± 0.2 mm and the mean peak systolic velocity of arterial blood flow was 44.7 ± 18.5 cm/s. When HIFU was applied at 5.5 kW/cm2, blood flow was completely occluded within 15 courses. HIFU exposure brought about vacuolar degeneration and destruction of elastic fibers in the tunica media of the artery. Conclusions: HIFU can be used to occlude umbilical artery blood flow in fetal rabbits.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalUltrasound in Obstetrics and Gynecology
Issue number1
Publication statusPublished - 2007 Jul


  • Animal experiment
  • Arterial occlusion
  • Fetal treatment
  • High-intensity focused ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology


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