Application of high-intensity focused ultrasound for fetal therapy: Experimental study using an animal model of lower urinary tract obstruction

Hiroko Aoki, Kiyotake Ichizuka, Mitsuyoshi Ichihara, Ryu Matsuoka, Junichi Hasegawa, Takashi Okai, Shinichirou Umemura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: The purpose of this study is to investigate whether high-intensity focused ultrasound (HIFU) exposure is able to produce a fistula between the bladder and abdominal wall of a fetus with lower urinary tract obstruction (LUTO). Materials and methods: We constructed a prototype HIFU transducer in combination with an imaging probe. HIFU was applied to the lower abdomen of a rabbit neonate that was complicated by LUTO as an experimental model to produce a fistula; HIFU was applied in a tank filled with degassed water. Exposed lesions were assessed by histological analysis at necropsy. Results: When HIFU was applied at 5.5 kW/cm2 of spatial-peak temporal average intensity (SPTA), a fistula was created between the lower abdominal wall and the urinary bladder; urine gushed out from the bladder through the fistula within 60 s after HIFU exposure. Conclusion: The findings suggest that fetal diseases such as LUTO can be non-invasively treated using HIFU exposure from even outside the maternal body, though this study was performed in a water tank.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of Medical Ultrasonics
Volume40
Issue number2
DOIs
Publication statusPublished - 2013 Apr 1

Keywords

  • Fetal therapy
  • HIFU
  • LUTO
  • Non-invasive

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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