Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats

Hayato Ikeda, Yoshihiko Hayashi, Naruto Takahashi, Tadashi Watabe, Yasukazu Kanai, Atsushi Shinohara, Hiroki Kato, Hiroshi Watabe, Eku Shimosegawa, Jun Hatazawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We proposed use of astatine-210 in preclinical study. Astatine-210 has higher yield of production and is easier to quantify than astatine-211. We produced astatine-210 with Bi target and 40 MeV alpha beam accelerated by cyclotron, free astatine-210 was separated and injected to normal rats. Three male rats (blocking group) were injected non-radioactive iodide before injection of astatine-210. Compared with the control group, the astatine-210 accumulations in the blocking group decreased to 24% in the thyroid.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalApplied Radiation and Isotopes
Volume139
DOIs
Publication statusPublished - 2018 Sep

ASJC Scopus subject areas

  • Radiation

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