Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans

E. Isogai, H. Isogai, T. Kubota, N. Fujii, S. Hayashi, T. Indoh, S. Takagi, H. Miura, K. Kimura

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor-alpha (TNF-α) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF-α are involved in apoptosis.

Original languageEnglish
Pages (from-to)529-537
Number of pages9
JournalJournal of Veterinary Medicine, Series B
Volume45
Issue number9
DOIs
Publication statusPublished - 1998 Nov

ASJC Scopus subject areas

  • Medicine(all)

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