Apoptosis Induction by Wheat-flour Sphingoid Bases in DLD-1 Human Colon Cancer Cells

Tatsuya Sugawara, Mikio Kinoshita, Masao Ohnishi, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.

Original languageEnglish
Pages (from-to)2228-2231
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number10
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Apoptosis
  • Colon cancer
  • Sphingoid bases
  • Wheat flour

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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