Apoptosis Induction by Wheat-flour Sphingoid Bases in DLD-1 Human Colon Cancer Cells

Tatsuya Sugawara; Mikio Kinoshita; Masao Ohnishi; Teruo Miyazawa

doi:10.1271/bbb.66.2228

Apoptosis Induction by Wheat-flour Sphingoid Bases in DLD-1 Human Colon Cancer Cells

Tatsuya Sugawara, Mikio Kinoshita, Masao Ohnishi, Teruo Miyazawa

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.

Original language	English
Pages (from-to)	2228-2231
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	66
Issue number	10
DOIs	https://doi.org/10.1271/bbb.66.2228
Publication status	Published - 2002 Jan 1

Keywords

Apoptosis
Colon cancer
Sphingoid bases
Wheat flour

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.66.2228

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abstract = "The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.",

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language = "English",

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AU - Sugawara, Tatsuya

AU - Kinoshita, Mikio

AU - Ohnishi, Masao

AU - Miyazawa, Teruo

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.

AB - The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.

KW - Apoptosis

KW - Colon cancer

KW - Sphingoid bases

KW - Wheat flour

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ER -

Apoptosis Induction by Wheat-flour Sphingoid Bases in DLD-1 Human Colon Cancer Cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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