Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Shuzo Sato, Glenn T. Gobbel, Jari Honkaniemi, Yibing Li, Takeo Kondo, Kensuke Murakami, Minako Sato, Jean Christophe Copin, Pak H. Chan

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalBrain research
Volume745
Issue number1-2
DOIs
Publication statusPublished - 1997 Jan 16

Keywords

  • 3-Nitropropionic acid
  • Apoptosis
  • DNA fragmentation
  • Huntington's disease
  • Mitochondria

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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