TY - JOUR
T1 - Apoptosis in cellular society
T2 - Communication between apoptotic cells and their neighbors
AU - Kawamoto, Yuhei
AU - Nakajima, Yu Ichiro
AU - Kuranaga, Erina
N1 - Funding Information:
We apologize to colleagues whose work could not be cited because of space limitations. We especially thank all the members of Kuranaga laboratory for valuable discussions. Studies by our group were supported in part by grants from the Naito Foundation (Yu-ichiro Nakajima), the Ichiro Kanehara Foundation (Yu-ichiro Nakajima), the Astellas Foundation for Research on Metabolic Disorders (Yu-ichiro Nakajima), the SGH Foundation (Yu-ichiro Nakajima), the Takeda Science Foundation (Erina Kuranaga), the Japan Foundation for Applied Enzymology (Erina Kuranaga), MEXT KAKENHI Grant Number JP26114003 (Erina Kuranaga), and the JSPS KAKENHI, grant numbers JP16H06634 (Yu-ichiro Nakajima), JP24687027 (Erina Kuranaga), and JP16H04800 (Erina Kuranaga).
Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/12/20
Y1 - 2016/12/20
N2 - Apoptosis is one of the cell-intrinsic suicide programs and is an essential cellular behavior for animal development and homeostasis. Traditionally, apoptosis has been regarded as a cell-autonomous phenomenon. However, recent in vivo genetic studies have revealed that apoptotic cells actively influence the behaviors of surrounding cells, including engulfment, proliferation, and production of mechanical forces. Such interactions can be bidirectional, and apoptosis is non-autonomously induced in a cellular community. Of note, it is becoming evident that active communication between apoptotic cells and living cells contributes to physiological processes during tissue remodeling, regeneration, and morphogenesis. In this review, we focus on the mutual interactions between apoptotic cells and their neighbors in cellular society and discuss issues relevant to future studies of apoptosis.
AB - Apoptosis is one of the cell-intrinsic suicide programs and is an essential cellular behavior for animal development and homeostasis. Traditionally, apoptosis has been regarded as a cell-autonomous phenomenon. However, recent in vivo genetic studies have revealed that apoptotic cells actively influence the behaviors of surrounding cells, including engulfment, proliferation, and production of mechanical forces. Such interactions can be bidirectional, and apoptosis is non-autonomously induced in a cellular community. Of note, it is becoming evident that active communication between apoptotic cells and living cells contributes to physiological processes during tissue remodeling, regeneration, and morphogenesis. In this review, we focus on the mutual interactions between apoptotic cells and their neighbors in cellular society and discuss issues relevant to future studies of apoptosis.
KW - Apoptosis
KW - Engulfment
KW - Mechanical force
KW - Non-cell autonomous effects
KW - Proliferation
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U2 - 10.3390/ijms17122144
DO - 10.3390/ijms17122144
M3 - Review article
C2 - 27999411
AN - SCOPUS:85007035442
VL - 17
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 12
M1 - 2144
ER -
