Apoptosis in cellular society: Communication between apoptotic cells and their neighbors

Yuhei Kawamoto, Yu Ichiro Nakajima, Erina Kuranaga

    Research output: Contribution to journalReview articlepeer-review

    35 Citations (Scopus)


    Apoptosis is one of the cell-intrinsic suicide programs and is an essential cellular behavior for animal development and homeostasis. Traditionally, apoptosis has been regarded as a cell-autonomous phenomenon. However, recent in vivo genetic studies have revealed that apoptotic cells actively influence the behaviors of surrounding cells, including engulfment, proliferation, and production of mechanical forces. Such interactions can be bidirectional, and apoptosis is non-autonomously induced in a cellular community. Of note, it is becoming evident that active communication between apoptotic cells and living cells contributes to physiological processes during tissue remodeling, regeneration, and morphogenesis. In this review, we focus on the mutual interactions between apoptotic cells and their neighbors in cellular society and discuss issues relevant to future studies of apoptosis.

    Original languageEnglish
    Article number2144
    JournalInternational journal of molecular sciences
    Issue number12
    Publication statusPublished - 2016 Dec 20


    • Apoptosis
    • Engulfment
    • Mechanical force
    • Non-cell autonomous effects
    • Proliferation

    ASJC Scopus subject areas

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry


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