Apolipoprotein L1 nephropathies: 2017 in review

Jeffrey B. Kopp, Hila Roshanravan, Koji Okamoto

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Purpose of review To review publications relating to apolipoprotein L1 (APOL1) renal risk variants published 2017. Recent findings The study of APOL1 variants continues to be highly active; 24 articles published in 2017 were selected to highlight. These include clinical studies of kidney disease, kidney transplantation, hypertension, cardiovascular disease, and genetic diversity. Laboratory studies included APOL1 association with vesicle-associated membrane soluble N-ethylmaleimide-sensitive factor activating protein receptor protein and with soluble urokinase-type plasminogen activator receptor, mitochondrial dysfunction, endolysosomal dysfunction, and inflammasome activation. Summary Our understanding of the role of APOL1 genetic variants and the mechanisms for renal toxicity continues to deepen. It is not yet clear which pathways are most relevant to human disease, and so, the most relevant drug targets remain to be defined.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalCurrent Opinion in Nephrology and Hypertension
Volume27
Issue number3
DOIs
Publication statusPublished - 2018 May 1
Externally publishedYes

Keywords

  • arterionephrosclerosis
  • endolysosomal trafficking
  • inflammasome
  • kidney transplantation
  • mitochondria
  • soluble urokinase-type plasminogen activator receptor

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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