Aplysianin-A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare, Aplysia kurodai

H. Kamiya, K. Muramoto, M. Yamazaki

    Research output: Contribution to journalArticlepeer-review

    55 Citations (Scopus)

    Abstract

    Aplysianin-A, an antibacterial and antineoplastic factor in the albumen gland of the sea hare Aplysia kurodai, was isolated. It had a molecular weight of approximately 320 kD and consisted of subunits with a molecular weight of 85 kD. It contained 9.8% neutral sugar. Aplysianin A showed 50% inhibition of Bacillus subtilis growth at a concentration of 4 μg protein/ml and 50% lysis of murine MM46 tumor cells at 14 ng protein/ml. A partial identity of antigenic specificity of the purified specimen with an antineoplastic factor from Aplysia eggs was observed in immunodiffusion tests.

    Original languageEnglish
    Pages (from-to)1065-1067
    Number of pages3
    JournalExperientia
    Volume42
    Issue number9
    DOIs
    Publication statusPublished - 1986 Sep 1

    Keywords

    • Antibacterial factor
    • Aplysia
    • albumen gland
    • antineoplastic factor
    • opisthobranch

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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