Abstract
Aplysianin-A, an antibacterial and antineoplastic factor in the albumen gland of the sea hare Aplysia kurodai, was isolated. It had a molecular weight of approximately 320 kD and consisted of subunits with a molecular weight of 85 kD. It contained 9.8% neutral sugar. Aplysianin A showed 50% inhibition of Bacillus subtilis growth at a concentration of 4 μg protein/ml and 50% lysis of murine MM46 tumor cells at 14 ng protein/ml. A partial identity of antigenic specificity of the purified specimen with an antineoplastic factor from Aplysia eggs was observed in immunodiffusion tests.
| Original language | English |
|---|---|
| Pages (from-to) | 1065-1067 |
| Number of pages | 3 |
| Journal | Experientia |
| Volume | 42 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1986 Sep 1 |
Keywords
- Antibacterial factor
- Aplysia
- albumen gland
- antineoplastic factor
- opisthobranch
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)