Apical ectodermal ridge induction by the transplantation of En-1- overexpressing ectoderm in chick limb bud

Mikiko Tanaka, Yasuyo Shigetani, Sayaka Sugiyama, Koji Tamura, Harukazu Nakamura, Hiroyuki Ide

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

In the early chick embryo, the dorsal-ventral (DV) boundary organizes the apical ectodermal ridge (AER) structure in the limb bud field. Here it is reported that Engrailed-1 (En-1), a homolog of the Drosophila segment polarity gene engrailed expressed in the ventral limb ectoderm, participates in AER formation at the DV boundary of the limb bud. Restricted ectopic expression of En-1 in the dorsal side of the limb bud by transplantation of En-1-overexpressing ectoderm induces ectopic AER at the boundary of En-1- positive and -negative cells. The results suggest that En-1 is involved in AER formation at the DV boundary of the limb bud.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalDevelopment Growth and Differentiation
Volume40
Issue number4
DOIs
Publication statusPublished - 1998 Jan 1

Keywords

  • Apical ectodermal ridge
  • Chick limb bud
  • Dorsal-ventral boundary
  • En-1

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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