Apatite-forming ability of polymers with carboxy groups in simulated body fluid

M. Kawashita, M. Nakao, M. Minoda, T. Miyamoto, H. M. Kim, T. Kokubo, T. Nakamura

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


Apatite-polymer composites with analogous structure to that of the natural bone are desired to be developed, since such composites are believed to show biological and mechanical properties similar to those of the natural bone. In the present study, apatite-forming ability of various kinds of polymers with or without carboxy (COOH) groups in simulated body fluid (SBF) was investigated. Carboxymethyl- (CM)- chitin and gellan gum gels, which have COOH groups, formed apatite on their surfaces within 3 d, when they were previously treated with saturated Ca(OH)2 solution. Calcium alginate gel with COOH groups formed apatite on its surface within 7 d without the Ca(OH)2-treatment, since calcium ions are previously incorporated into the gel structure in the gel-forming process. In contrast, curdlan gel without COOH groups did not form the apatite on its surface within 14 d even after the Ca(OH)2-treatment. These results indicate that the COOH groups on a polymer surface are effective for the apatite nucleation and the apatite-forming ability of the polymer can be improved by incorporation of the calcium ions. In conclusion, these types of polymers are promising candidates for obtaining apatite-polymer composites with bonelike structure by a biomimetic process.

Original languageEnglish
Pages (from-to)697-700
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2001
Externally publishedYes
Event13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
Duration: 2000 Nov 222000 Nov 26

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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