TY - JOUR
T1 - Apatite-forming ability of glass-ceramic apatite-wollastonite - Polyethylene composites
T2 - Effect of filler content
AU - Juhasz, J. A.
AU - Best, S. M.
AU - Bonfield, W.
AU - Kawashita, M.
AU - Miyata, N.
AU - Kokubo, T.
AU - Nakamura, T.
N1 - Funding Information:
The authors would like to thank Nippon Electric Glass Co., Japan, for supplying particulate glass-ceramic A–W. Thanks also to Dr W. McGregor and Prof. K. E. Tanner. (both at the IRC in Biomedical Materials, London, England) for production of all composites. Thanks also to Ms P. Jha and Mr M. Greaves of the Department of Earth Sciences, University of Cambridge, for help with the ICP-AES testing. Support from the UK EPSRC is gratefully acknowledged as is the scholarship provided by YKK (UK) Ltd. enabling J. A. Juhasz to continue research in Japan.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - The bioactivity of a range of glass-ceramic apatite-wollastonite (A-W) - polyethylene composites (AWPEXs) with glass-ceramic A-W volume percentages ranging from 10 to 50, has been investigated in an acellular simulated body fluid (SBF) with ion concentrations similar to those of human blood plasma. The formation of a biologicallyactive apatite layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction (TF-XRD) and field-emission scanning electron microscopy (FE-SEM). An apatite layer was formed on all the composites, with the rate of formation increasing with an increase in glass-ceramic A-W percentage. For composites with glass-ceramic A-W filler contents ≥30 vol%, the apatite layer was formed within 12h of immersion, which is a comparable time for apatite formation on monolithic glass-ceramic A-W. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) demonstrated that the apatite formation on AWPEX samples with 50vol% filler content occurred in a manner similartothatseen on pure glass-ceramic A-W, in that the calcium, silicon, and magnesium ion concentrations increased and, conversely, a decrease was observed in the phosphate ion concentration. These results indicate that a suitable in vitro response was achieved on a composite incorporating particulate glass-ceramic A-W with a particularly favorable response being observed on the AWPEX sample with 50vol% filler content.
AB - The bioactivity of a range of glass-ceramic apatite-wollastonite (A-W) - polyethylene composites (AWPEXs) with glass-ceramic A-W volume percentages ranging from 10 to 50, has been investigated in an acellular simulated body fluid (SBF) with ion concentrations similar to those of human blood plasma. The formation of a biologicallyactive apatite layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction (TF-XRD) and field-emission scanning electron microscopy (FE-SEM). An apatite layer was formed on all the composites, with the rate of formation increasing with an increase in glass-ceramic A-W percentage. For composites with glass-ceramic A-W filler contents ≥30 vol%, the apatite layer was formed within 12h of immersion, which is a comparable time for apatite formation on monolithic glass-ceramic A-W. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) demonstrated that the apatite formation on AWPEX samples with 50vol% filler content occurred in a manner similartothatseen on pure glass-ceramic A-W, in that the calcium, silicon, and magnesium ion concentrations increased and, conversely, a decrease was observed in the phosphate ion concentration. These results indicate that a suitable in vitro response was achieved on a composite incorporating particulate glass-ceramic A-W with a particularly favorable response being observed on the AWPEX sample with 50vol% filler content.
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U2 - 10.1023/A:1023499728588
DO - 10.1023/A:1023499728588
M3 - Article
C2 - 15348432
AN - SCOPUS:0038356553
SN - 0957-4530
VL - 14
SP - 489
EP - 495
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 6
ER -