Apatite-forming ability of alginate fibers treated with calcium hydroxide solution

T. Kokubo, M. Hanakawa, M. Kawashita, M. Minoda, T. Beppu, T. Miyamoto, T. Nakamura

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Calcium alginate fibers were prepared by extruding an aqueous sodium alginate solution into an aqueous calcium chloride solution. The fibers were treated with a saturated aqueous calcium hydroxide solution for various periods and their apatite-forming ability was examined in a simulated body fluid (SBF). The calcium alginate fibers were treated with the aqueous calcium hydroxide solution for periods longer than five days formed apatite on their surfaces in SBF, and their apatite-forming ability improved with increasing calcium hydroxide treatment time. The amount of calcium ions released from the fibers also increased with increasing calcium hydroxide treatment time, resulting in acceleration of nucleation and growth of apatite on the fiber surfaces. The resultant apatite-alginate fiber composite is expected to be useful as a flexible bioactive bone-repairing material.

Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume15
Issue number9
DOIs
Publication statusPublished - 2004 Sep 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Kokubo, T., Hanakawa, M., Kawashita, M., Minoda, M., Beppu, T., Miyamoto, T., & Nakamura, T. (2004). Apatite-forming ability of alginate fibers treated with calcium hydroxide solution. Journal of Materials Science: Materials in Medicine, 15(9), 1007-1012. https://doi.org/10.1023/B:JMSM.0000042686.44977.81