TY - JOUR
T1 - Apatite-forming ability and mechanical properties of PTMO-modified CaO-SiO2 hybrids prepared by sol-gel processing
T2 - Effect of CaO and PTMO contents
AU - Miyata, Noboru
AU - Fuke, Ken Ichi
AU - Chen, Qi
AU - Kawashita, Masakazu
AU - Kokubo, Tadashi
AU - Nakamura, Takashi
N1 - Funding Information:
This work was supported by The Special Coordination Fund of the Ministry of Education, Culture, Sports, Science and Technology of Japan, Research on Creation of Biointegrated Materials to Improve Physically Handicapped People’s Quality of Life.
PY - 2002
Y1 - 2002
N2 - Transparent monolithics of triethoxysilane end-capped poly(tetramethylene oxide) (Si-PTMO)-modified CaO-SiO2 hybrids were successfully synthesized by hydrolysis and polycondensation of Si-PTMO, tetraethoxysilane (TEOS) and calcium nitrate. As for the samples with varying (Ca(NO3)2)/(TEOS) molar ratios under constant ratio of (Si-PTMO)/(TEOS) of 2/3 in weight, the apatite-forming ability in a simulated body fluid (SBF) which is indicative of bioactivity, remarkably increased with increasing CaO content, although the tensile strength and Young's modulus decreased. The hybrid with (Ca(NO3)2)/(TEOS)=0.15 in mol formed an apatite on its surface within only 1 day. For this series of samples, the strain at failure which is a measure of capability for deformation of material, was found to be about 30% and almost independent of CaO content. As for the samples with varying (Si-PTMO)/(TEOS) weight ratios under constant ratio of (Ca(NO3)2)/(TEOS) of 0.15 in mol, the strain at failure increased with increasing Si-PTMO content, but the apatite-forming ability, tensile strength and Young's modulus decreased. Thus, the synthesis of the hybrids exhibiting both high apatite-forming ability and high extensibility can be achieved by selecting suitable CaO and Si-PTMO contents. These new kind of hybrid materials may be useful as bioactive bone-repairing materials.
AB - Transparent monolithics of triethoxysilane end-capped poly(tetramethylene oxide) (Si-PTMO)-modified CaO-SiO2 hybrids were successfully synthesized by hydrolysis and polycondensation of Si-PTMO, tetraethoxysilane (TEOS) and calcium nitrate. As for the samples with varying (Ca(NO3)2)/(TEOS) molar ratios under constant ratio of (Si-PTMO)/(TEOS) of 2/3 in weight, the apatite-forming ability in a simulated body fluid (SBF) which is indicative of bioactivity, remarkably increased with increasing CaO content, although the tensile strength and Young's modulus decreased. The hybrid with (Ca(NO3)2)/(TEOS)=0.15 in mol formed an apatite on its surface within only 1 day. For this series of samples, the strain at failure which is a measure of capability for deformation of material, was found to be about 30% and almost independent of CaO content. As for the samples with varying (Si-PTMO)/(TEOS) weight ratios under constant ratio of (Ca(NO3)2)/(TEOS) of 0.15 in mol, the strain at failure increased with increasing Si-PTMO content, but the apatite-forming ability, tensile strength and Young's modulus decreased. Thus, the synthesis of the hybrids exhibiting both high apatite-forming ability and high extensibility can be achieved by selecting suitable CaO and Si-PTMO contents. These new kind of hybrid materials may be useful as bioactive bone-repairing materials.
KW - Apatite-forming ability
KW - Bioactivity
KW - Mechanical properties
KW - Organic-inorganic hybrids
KW - Poly(tetramethylene oxide)
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U2 - 10.1016/S0142-9612(02)00065-0
DO - 10.1016/S0142-9612(02)00065-0
M3 - Article
C2 - 12069346
AN - SCOPUS:0036013943
VL - 23
SP - 3033
EP - 3040
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 14
ER -