Apatite formation on synthetic polypeptide with β sheet structure in a solution mimicking body environment

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin Ichi Ogata, Masao Tanihara, Toshiki Miyazaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Our previous study presented that sericin, a kind of silk protein, had high ability of apatite formation under a condition mimicking body environment when the sericin contains high content of β sheet structure. To confirm the effectiveness of β sheet structure on apatite nucleation, we attempted to synthesize of polypeptide containing β sheet structure and investigate apatite formation in 1.5SBF that has 1.5 times the inorganic ion concentrations of human blood plasma. Poly(FEFEFEFG) was synthesized as the polypeptide consisting mainly of β sheet structure. Formation of hydroxyapatite was observed on the film of the poly(FEFEFEFG) after soaking in 1.5SBF within 7 days. We could confirm that β sheet structure was effective even in the synthetic polypeptide.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes

Keywords

  • Biomimetic process
  • Hydroxyapatite
  • Peptide
  • Simulated body fluid (SBF)
  • β sheet

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Apatite formation on synthetic polypeptide with β sheet structure in a solution mimicking body environment'. Together they form a unique fingerprint.

  • Cite this