Apatite formation on non-woven fabric of carboxymethylated chitin in SBF

Tadashi Kokubo; Masayuki Hanakawa; Masakazu Kawashita; Masahiko Minoda; Toshiyuki Beppu; Takeaki Miyamoto; Takashi Nakamura

doi:10.1016/j.biomaterials.2003.11.007

Apatite formation on non-woven fabric of carboxymethylated chitin in SBF

Tadashi Kokubo, Masayuki Hanakawa, Masakazu Kawashita, Masahiko Minoda, Toshiyuki Beppu, Takeaki Miyamoto, Takashi Nakamura

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Chitin fibres constituting a non-woven fabric were carboxymethylated in monochloro acetic acid and treated with saturated Ca(OH)₂ aqueous solution. Within 3 days in a simulated body fluid with pH value and ion concentrations nearly equal to those of human blood plasma, a bonelike apatite layer formed on the surface of fibres of the treated fabric. The apatite-chitin fibre composite thus prepared is expected to be useful as a flexible bioactive bone-repairing material.

Original language	English
Pages (from-to)	4485-4488
Number of pages	4
Journal	Biomaterials
Volume	25
Issue number	18
DOIs	https://doi.org/10.1016/j.biomaterials.2003.11.007
Publication status	Published - 2004 Aug

Keywords

Apatite
Biomimetic process
Carboxyl groups
Carboxymethylated chitin
Non-woven fabric
Simulated body fluid

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2003.11.007

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title = "Apatite formation on non-woven fabric of carboxymethylated chitin in SBF",

abstract = "Chitin fibres constituting a non-woven fabric were carboxymethylated in monochloro acetic acid and treated with saturated Ca(OH)2 aqueous solution. Within 3 days in a simulated body fluid with pH value and ion concentrations nearly equal to those of human blood plasma, a bonelike apatite layer formed on the surface of fibres of the treated fabric. The apatite-chitin fibre composite thus prepared is expected to be useful as a flexible bioactive bone-repairing material.",

keywords = "Apatite, Biomimetic process, Carboxyl groups, Carboxymethylated chitin, Non-woven fabric, Simulated body fluid",

author = "Tadashi Kokubo and Masayuki Hanakawa and Masakazu Kawashita and Masahiko Minoda and Toshiyuki Beppu and Takeaki Miyamoto and Takashi Nakamura",

note = "Funding Information: This research was partially supported by Grant-in-Aid for Scientific Research (C), 13680934, Japan Society for the Promotion of Science.",

year = "2004",

month = aug,

doi = "10.1016/j.biomaterials.2003.11.007",

language = "English",

volume = "25",

pages = "4485--4488",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

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T1 - Apatite formation on non-woven fabric of carboxymethylated chitin in SBF

AU - Kokubo, Tadashi

AU - Hanakawa, Masayuki

AU - Kawashita, Masakazu

AU - Minoda, Masahiko

AU - Beppu, Toshiyuki

AU - Miyamoto, Takeaki

AU - Nakamura, Takashi

N1 - Funding Information: This research was partially supported by Grant-in-Aid for Scientific Research (C), 13680934, Japan Society for the Promotion of Science.

PY - 2004/8

Y1 - 2004/8

N2 - Chitin fibres constituting a non-woven fabric were carboxymethylated in monochloro acetic acid and treated with saturated Ca(OH)2 aqueous solution. Within 3 days in a simulated body fluid with pH value and ion concentrations nearly equal to those of human blood plasma, a bonelike apatite layer formed on the surface of fibres of the treated fabric. The apatite-chitin fibre composite thus prepared is expected to be useful as a flexible bioactive bone-repairing material.

AB - Chitin fibres constituting a non-woven fabric were carboxymethylated in monochloro acetic acid and treated with saturated Ca(OH)2 aqueous solution. Within 3 days in a simulated body fluid with pH value and ion concentrations nearly equal to those of human blood plasma, a bonelike apatite layer formed on the surface of fibres of the treated fabric. The apatite-chitin fibre composite thus prepared is expected to be useful as a flexible bioactive bone-repairing material.

KW - Apatite

KW - Biomimetic process

KW - Carboxyl groups

KW - Carboxymethylated chitin

KW - Non-woven fabric

KW - Simulated body fluid

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DO - 10.1016/j.biomaterials.2003.11.007

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SP - 4485

EP - 4488

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 18

ER -

Apatite formation on non-woven fabric of carboxymethylated chitin in SBF

Abstract

Keywords

ASJC Scopus subject areas

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