Apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate

A. Oyane, M. Minoda, T. Miyamoto, K. Nakanishi, M. Kawashita, T. Kokubo, T. Nakamura

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)

Abstract

Silanol (Si-OH) groups on materials are believed to induce the apatite nucleation in the body environment. In the present study, the apatite-forming ability of ethylene-vinyl alcohol copolymer (EVOH), whose surface was modified to be abundant in Si-OH groups, was investigated in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. Surface modification of EVOH with Si-OH groups was carried out by reacting isocyanatopropyltriethoxysilane (IPTS) and subsequent hydrolysis of its Si-OC2H5 groups by 1M-HCl or saturated Ca(OH)2 aqueous solution. Apatite was, however, not formed on thus surface-modified EVOH in SBF even after 7 d. When the IPTS-treated EVOH was treated with silica or calcium silicate solution, the obtained specimen formed the apatite on its surface in SBF within 7 or 2 d, respectively. The present surface-modification of EVOH is effective for obtaining an apatite-polymer fiber composite in SBF, which could give bone substitute having bone-bonding ability as well as mechanical properties analogous to those of the natural bone.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001 Jan 1
Event13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
Duration: 2000 Nov 222000 Nov 26

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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