Apatite Deposition on Silk Sericin in a Solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin Ichi Ogata, Masao Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani, Hisao Kinoshita

Research output: Contribution to journalConference articlepeer-review

4 Citations (Scopus)

Abstract

An apatite-organic polymer hybrid is expected as a novel material for medical application, because it shows high biological affinity and high flexibility. In order to fabricate this type of hybrid, a biomimetic process was proposed, in which a bone-like apatite layer can be coated onto organic substrates by using a simulated body fluid (SBF) at ambient conditions. Potential of induction of heterogeneous nucleation of apatite on substrate materials is an important parameter to achieve a successful coating of apatite. Recently, it was reported that sericin, a protein existing on the surface of raw silk fiber, showed apatite-forming ability in 1.5 SBF which has 1.5 times the ion concentrations of SBF. In the present study, the structural effect of sericin on its apatite-forming ability was investigated in 1.5SBF. Apatite was deposited on sericin with high molecular weight and β-sheet structure in 1.5SBF after 7 days.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalKey Engineering Materials
Volume254-256
Publication statusPublished - 2004 Jan 1
Externally publishedYes
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: 2003 Nov 62003 Nov 9

Keywords

  • Biomimetic process
  • Hydroxyapatite
  • Sericin
  • Simulated body fluid

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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