Apatite Deposition on Silk Sericin in a Solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film

Akari Takeuchi; Chikara Ohtsuki; Masanobu Kamitakahara; Shin Ichi Ogata; Masao Tanihara; Toshiki Miyazaki; Masao Yamazaki; Yoshiaki Furutani; Hisao Kinoshita

Apatite Deposition on Silk Sericin in a Solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin Ichi Ogata, Masao Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani, Hisao Kinoshita

Research output: Contribution to journal › Conference article › peer-review

4 Citations (Scopus)

Abstract

An apatite-organic polymer hybrid is expected as a novel material for medical application, because it shows high biological affinity and high flexibility. In order to fabricate this type of hybrid, a biomimetic process was proposed, in which a bone-like apatite layer can be coated onto organic substrates by using a simulated body fluid (SBF) at ambient conditions. Potential of induction of heterogeneous nucleation of apatite on substrate materials is an important parameter to achieve a successful coating of apatite. Recently, it was reported that sericin, a protein existing on the surface of raw silk fiber, showed apatite-forming ability in 1.5 SBF which has 1.5 times the ion concentrations of SBF. In the present study, the structural effect of sericin on its apatite-forming ability was investigated in 1.5SBF. Apatite was deposited on sericin with high molecular weight and β-sheet structure in 1.5SBF after 7 days.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	Key Engineering Materials
Volume	254-256
Publication status	Published - 2004 Jan 1
Externally published	Yes
Event	The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: 2003 Nov 6 → 2003 Nov 9

Keywords

Biomimetic process
Hydroxyapatite
Sericin
Simulated body fluid

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Apatite Deposition on Silk Sericin in a Solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film",

abstract = "An apatite-organic polymer hybrid is expected as a novel material for medical application, because it shows high biological affinity and high flexibility. In order to fabricate this type of hybrid, a biomimetic process was proposed, in which a bone-like apatite layer can be coated onto organic substrates by using a simulated body fluid (SBF) at ambient conditions. Potential of induction of heterogeneous nucleation of apatite on substrate materials is an important parameter to achieve a successful coating of apatite. Recently, it was reported that sericin, a protein existing on the surface of raw silk fiber, showed apatite-forming ability in 1.5 SBF which has 1.5 times the ion concentrations of SBF. In the present study, the structural effect of sericin on its apatite-forming ability was investigated in 1.5SBF. Apatite was deposited on sericin with high molecular weight and β-sheet structure in 1.5SBF after 7 days.",

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author = "Akari Takeuchi and Chikara Ohtsuki and Masanobu Kamitakahara and Ogata, {Shin Ichi} and Masao Tanihara and Toshiki Miyazaki and Masao Yamazaki and Yoshiaki Furutani and Hisao Kinoshita",

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T2 - The Annual Meeting of the International Society for Ceramics in Medicine

AU - Takeuchi, Akari

AU - Ohtsuki, Chikara

AU - Kamitakahara, Masanobu

AU - Ogata, Shin Ichi

AU - Tanihara, Masao

AU - Miyazaki, Toshiki

AU - Yamazaki, Masao

AU - Furutani, Yoshiaki

AU - Kinoshita, Hisao

PY - 2004/1/1

Y1 - 2004/1/1

N2 - An apatite-organic polymer hybrid is expected as a novel material for medical application, because it shows high biological affinity and high flexibility. In order to fabricate this type of hybrid, a biomimetic process was proposed, in which a bone-like apatite layer can be coated onto organic substrates by using a simulated body fluid (SBF) at ambient conditions. Potential of induction of heterogeneous nucleation of apatite on substrate materials is an important parameter to achieve a successful coating of apatite. Recently, it was reported that sericin, a protein existing on the surface of raw silk fiber, showed apatite-forming ability in 1.5 SBF which has 1.5 times the ion concentrations of SBF. In the present study, the structural effect of sericin on its apatite-forming ability was investigated in 1.5SBF. Apatite was deposited on sericin with high molecular weight and β-sheet structure in 1.5SBF after 7 days.

AB - An apatite-organic polymer hybrid is expected as a novel material for medical application, because it shows high biological affinity and high flexibility. In order to fabricate this type of hybrid, a biomimetic process was proposed, in which a bone-like apatite layer can be coated onto organic substrates by using a simulated body fluid (SBF) at ambient conditions. Potential of induction of heterogeneous nucleation of apatite on substrate materials is an important parameter to achieve a successful coating of apatite. Recently, it was reported that sericin, a protein existing on the surface of raw silk fiber, showed apatite-forming ability in 1.5 SBF which has 1.5 times the ion concentrations of SBF. In the present study, the structural effect of sericin on its apatite-forming ability was investigated in 1.5SBF. Apatite was deposited on sericin with high molecular weight and β-sheet structure in 1.5SBF after 7 days.

KW - Biomimetic process

KW - Hydroxyapatite

KW - Sericin

KW - Simulated body fluid

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AN - SCOPUS:0346885579

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JO - Key Engineering Materials

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Y2 - 6 November 2003 through 9 November 2003

ER -

Apatite Deposition on Silk Sericin in a Solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film

Abstract

Keywords

ASJC Scopus subject areas

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