Antiviral activity of proanthocyanidin against feline calicivirus used as a surrogate for noroviruses, and coxsackievirus used as a representative enteric virus

Atsuo Iwasawa, Yoshimi Niwano, Takayuki Mokudai, Masahiro Kohno

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Proanthocyanidin, which consists of (+) catechin, (-) epicatechin and their gallates (15%), (-) epicatechin gallate-dimers, -trimers, and -tetramers (80%), and (-) epicatechin gallate-pentamers, -hexamers, and -heptamers (.5%), was evaluated for its antiviral activity against feline calicivirus F9 strain (FCV/F9), which is thought to be a surrogate for noroviruses, and coxsackievirus A7 strain (Cox.A7), which was selected as a representative enteric virus. To achieve a viral inactivation rate of 99% or greater after contact for 10 sec., at least 1 mg/ml and 10 mg/ml of proanthocyanidin were required against FCV/F9 and Cox.A7, respectively. Although the antiviral mechanism of proanthocyanidin is not clear at present, proanthocyanidin may be an effective disinfectant against enteroviruses such as noroviruses.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalBiocontrol Science
Volume14
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Coxsackievirus
  • Feline calicivirus
  • Norovirus
  • Proanthocyanidin

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health

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