Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex

Kazuaki Sasaki; Nagahiko Yumita; Ryuichiro Nishigaki; Shin Ichiro Umemura

doi:10.1111/j.1349-7006.1998.tb00584.x

Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex

Kazuaki Sasaki, Nagahiko Yumita, Ryuichiro Nishigaki, Shin Ichiro Umemura

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm² or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm² or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm².

Original language	English
Pages (from-to)	452-456
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	89
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.1998.tb00584.x
Publication status	Published - 1998 Apr
Externally published	Yes

Keywords

Antitumor effect
Focused ultrasound
Porphyrin complex
Sonodynamic therapy
Walker 256

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1998.tb00584.x

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title = "Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex",

abstract = "The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.",

keywords = "Antitumor effect, Focused ultrasound, Porphyrin complex, Sonodynamic therapy, Walker 256",

author = "Kazuaki Sasaki and Nagahiko Yumita and Ryuichiro Nishigaki and Umemura, {Shin Ichiro}",

year = "1998",

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doi = "10.1111/j.1349-7006.1998.tb00584.x",

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AU - Sasaki, Kazuaki

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AU - Nishigaki, Ryuichiro

AU - Umemura, Shin Ichiro

PY - 1998/4

Y1 - 1998/4

N2 - The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.

AB - The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.

KW - Antitumor effect

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KW - Porphyrin complex

KW - Sonodynamic therapy

KW - Walker 256

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Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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