TY - JOUR
T1 - Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex
AU - Sasaki, Kazuaki
AU - Yumita, Nagahiko
AU - Nishigaki, Ryuichiro
AU - Umemura, Shin Ichiro
PY - 1998/4
Y1 - 1998/4
N2 - The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.
AB - The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.
KW - Antitumor effect
KW - Focused ultrasound
KW - Porphyrin complex
KW - Sonodynamic therapy
KW - Walker 256
UR - http://www.scopus.com/inward/record.url?scp=0031981190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031981190&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.1998.tb00584.x
DO - 10.1111/j.1349-7006.1998.tb00584.x
M3 - Article
C2 - 9617352
AN - SCOPUS:0031981190
VL - 89
SP - 452
EP - 456
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 4
ER -
