Abstract
The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.
Original language | English |
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Pages (from-to) | 452-456 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer Research |
Volume | 89 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1998 Apr |
Externally published | Yes |
Keywords
- Antitumor effect
- Focused ultrasound
- Porphyrin complex
- Sonodynamic therapy
- Walker 256
ASJC Scopus subject areas
- Oncology
- Cancer Research