Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex

Kazuaki Sasaki; Nagahiko Yumita; Ryuichiro Nishigaki; Shin Ichiro Umemura

doi:10.1111/j.1349-7006.1998.tb00584.x

Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex

Kazuaki Sasaki, Nagahiko Yumita, Ryuichiro Nishigaki, Shin Ichiro Umemura

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm² or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm² or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm².

Original language	English
Pages (from-to)	452-456
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	89
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.1998.tb00584.x
Publication status	Published - 1998 Apr

Keywords

Antitumor effect
Focused ultrasound
Porphyrin complex
Sonodynamic therapy
Walker 256

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Antitumor effect sonodynamically induced by focused ultrasound in combination with Ga-porphyrin complex",

abstract = "The antitumor effect of focused ultrasound in combination with Ga-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17 tetramethylporphyrin-2,18-dipropionyl diaspartic acid (ATX-70), on the growth of experimental murine tumors was examined. Walker 256 tumors implanted in rat kidneys were exposed in a progressive wave field for 5 min to focused ultrasound at 500 kHz with the second harmonic (at 1 MHz) superimposed after administration of ATX-70 to the rats. A significant antitumor effect was obtained at a focal-spot average acoustic intensity of 12 W/cm2 or higher with an ATX-70 dose of not less than 2.5 mg/kg. When the acoustic intensity was 8 W/cm2 or lower no significant effect was observed even at an ATX-70 dose of 2.5 mg/kg. Also when the ATX-70 dose was 1.0 mg/kg or lower, no significant effect was observed even at a focal-spot average acoustic intensity of 40 W/cm2.",

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author = "Kazuaki Sasaki and Nagahiko Yumita and Ryuichiro Nishigaki and Umemura, {Shin Ichiro}",

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