Antitumor effect of sonodynamically activated pyrrolidine tris-acid fullerene

Yumiko Iwase, Koji Nishi, Junya Fujimori, Toshio Fukai, Nagahiko Yumita, Toshihiko Ikeda, Fu Shin Chen, Yasunori Momose, Shin Ichiro Umemura

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2 Citations (Scopus)


In this study, the sonodynamically induced antitumor effect of pyrrolidine tris-acid fullerene (PTF) was investigated. Sonodynamically induced antitumor effects of PTF by focused ultrasound were investigated using isolated sarcoma-180 cells and mice bearing ectopically-implanted colon 26 carcinoma. Cell damage induced by ultrasonic exposure was enhanced by 5-fold in the presence of 80μM PTF. The combined treatment of ultrasound and PTF suppressed the growth of the implanted colon 26 carcinoma. Ultrasonically induced 2,2,6,6-tetramethyl-4-piperidone-1-oxyl (4oxoTEMPO) production in the presence and absence of PTF was assessed, and it was shown that 80μM PTF enhanced 4oxoTEMPO production as measured by ESR spectroscopy. Histidine, a reactive oxygen scavenger, significantly reduced cell damage and 4oxoTEMPO generation caused by ultrasonic exposure in the presence of PTF. These results suggest that singlet oxygen is likely to be involved in the ultrasonically induced cell damage enhanced by PTF.

Original languageEnglish
Article number07KF02
JournalJapanese journal of applied physics
Issue number7
Publication statusPublished - 2016 Jul

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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