Antitumor effect of recombinant human interferon ɑa/d on meth-a sarcoma in mice

Osamu Yoshie, Hisashi Aso, Masaki Nanjo, Keiji Tamura, Takusaburo Ebina, Nakao Ishida

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Recombinant human inrerferon ɑA/D (IFNɑA/D) is known to be as active on murine cells as on human cells. We studied the antitumor effect of pure IFNɑA/D on Meth-A sarcoma subcutaneously transplanted into female syngeneic BALB/c mice. When administered systematically (intraperitoneally), IFNɑA/D was only marginally (but significantly, P<0.05) effective in inhibiting tumor growth. With intralesional injection, however, IFNɑA/D strongly suppressed the growth of Meth-A sarcoma, even leading to complete tumor regression and to subsequent immunity to Meth-A sarcoma cells in the host mice when the treatment was started early after tumor transplantation and with a high IFNɑA/D dose. We also found that treatment of mice with IFNɑA/D increased the level of serum ɑ1-acid glycoprotein, one of the acute-phase proteins.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalJapanese Journal of Cancer Research GANN
Volume77
Issue number4
Publication statusPublished - 1986 Jan 1

Keywords

  • Antitumor effect
  • Interferon
  • Meth-A sarcoma— ɑ-Acid glycoprotein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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