Antitumor effect of a novel fullerene-based photosensitizer with magnetic resonance imaging ability

Jian Liu, Masaya Yamamoto, Masatoshi Yamada, Shin Ichi Ohta, Akinaga Sonoda, Norihisa Nitta, Kiyoshi Murata, Yasuhiko Tabata

Research output: Contribution to conferencePaperpeer-review

Abstract

A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C60, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C60 prepared. After the DTPA-introduced C 60-PEG was mixed with gadolinium ions (Gd3+) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd 3+ ions enabled the C60-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.

Original languageEnglish
Pages1987
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Antitumor activity
  • Fullerene
  • Magnetic resonance imaging
  • Photodynamic therapy
  • Tumor targeting

ASJC Scopus subject areas

  • Engineering(all)

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