Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.

Keisuke Tachibana, Tatsuya Katayama, Chihiro Ueda, Mikako Sumitomo, Masayuki Tagami, Kenji Ishimoto, Daisuke Yamasaki, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Satoshi Obika, Takeshi Imanishi, Takefumi Doi

Research output: Contribution to journalArticlepeer-review

Abstract

2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) is a nucleic acid analogue that has high affinity binding to its complementary RNA. Peroxisome proliferator-activated receptor (PPAR) y belongs to the nuclear hormone receptor superfamily and is a drug target in the treatment of type 2 diabetes. Here, we show the antisense effects of 2',4'-BNA oligonucleotides against PPARy in the human monocytic leukaemia cell line THP-1 and the human colorectal tumor cell line HCT116.

Original languageEnglish
Pages (from-to)441-442
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
DOIs
Publication statusPublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.'. Together they form a unique fingerprint.

Cite this