Antiplatelet therapy for prevention of thromboembolic complications associated with coil embolization of unruptured cerebral aneurysms

Yasushi Matsumoto, Ryushi Kondo, Yasuhiko Matsumori, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Antiplatelet agents are used during endovascular treatment of cerebral aneurysms to prevent thromboembolic complications. Objective: The aim of this study was to investigate the efficacy of clopidogrel for the prevention of thromboembolic complications during elective coil embolization of unruptured cerebral aneurysms. Methods: Sixty-three patients prospectively received oral clopidogrel 75mg/day from 3 days before and for 1 day after the procedure at our institute (Kohnan Hospital, Sendai, Japan) during 2007. Results: At 24 hours post-coiling, significantly less high-intensity areas, detected by MRI with diffusion-weighted imaging (MRI-DWI), were observed in clopidogrel-treated patients compared with a historical control cohort of aspirin (acetylsalicylic acid)-treated patients (13/63 [20.6%] vs 27/69 [39.1%]; p = 0.02), primarily due to a statistically significantly lower rate during repair of small (<10mm) lesions (p = 0.008).Also, the rate of periprocedural thromboembolic events was lower in the clopidogrel than the aspirin cohort (2/63 [3.2%] vs 5/69 [7.2%]; p = 0.3). Conclusions: Clopidogrel was generally well tolerated with no signs of hemorrhagic complications or liver dysfunction.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalDrugs in R and D
Volume12
Issue number1
DOIs
Publication statusPublished - 2012 Mar 26

Keywords

  • Aspirin
  • Clopidogrel
  • Intracranial-aneurysm
  • Thromboembolism

ASJC Scopus subject areas

  • Pharmacology

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