Antioxidative and anti-inflammatory actions of reactive cysteine persulfides

Tianli Zhang, Hiroyasu Tsutsuki, Katushiko Ono, Takaaki Akaike, Tomohiro Sawa

Research output: Contribution to journalReview articlepeer-review

Abstract

Cysteine persulfide (CysSSH) and polysulfides (CysS[S]nH, n>1) are cysteine derivatives having sulfane sulfur atoms bound to cysteine thiol. Recent advances in the development of analytical methods for detection and quantification of persulfides and polysulfides have revealed the biological presence, in both prokaryotes and eukaryotes, of persulfide/polysulfide in diverse forms such as CysSSH, glutathione persulfide and protein persulfides. Accumu-lating evidence has suggested that persulfide/polysulfide species may involve in a variety of biological events such as biosyntheses of sulfur-containing molecules, tRNA modification, regulation of redox-dependent signal transduction, mitochondrial energy metabolism via sulfur respiration, cytoprotection from oxidative stress via their antioxidant activities, and anti-inflammation against Toll-like receptor-mediated inflammatory responses. Development of chemical sulfur donors may facilitate further understanding of physiological and pathophysiological roles of persulfide/polysulfide species, including regulatory roles of these species in immune responses.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Volume68
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Keywords

  • Anti-inflammatory effect
  • Antioxidant
  • Electrophile
  • Persulfide
  • Reactive sulfur species

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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