Antinociceptive effects of landiolol and esmolol

Eiji Masaki

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Besides its cardioinhibitory effects, short-acting β1- adrenergic receptor antagonists, landiolol and esmolol are reported to exert antinociceptive and anesthetic sparing effects in animal and human subjects. For example, esmolol reduces the anesthetic requirements for skin incision during propofol/N2O and morphine anesthesia in human and inhibits nociceptive responses following formalin injection in rats. It is also suggested that landiolol decreases BIS response to tracheal intubation during sevoflurane anesthesia. Several possible mechanisms, such as changing pharmacokinetics of opioid and implication with inhibitory G protein, for short-acting β1-adrenergic receptor antagonists to produce antinociceptive effects were proposed. However, direct mechanism underling antinociceptive effects of short-acting β1-adrenergic receptor antagonists has not been fully established. The merits to use short-acting β1- adrenergic receptor antagonists as anesthetic adjuvants could be to reduce anesthetic and opioid requirements (thus, to avoid its side effects such as nausea and vomiting), to maintain hemodynamic stability, and to achieve early recovery from anesthesia. Administration of a sufficient dose of a short-acting β1-adrenergic receptor antagonist, for example by neuraxial route, may potentially be a new treatment strategy for the perioperative pain, although further study is necessary to establish its efficacy and toxicity. Short-acting β1-adrenergic receptor antagonists will be used as agents for antinociception in future.

Original languageEnglish
Pages (from-to)849-855
Number of pages7
JournalJapanese Journal of Anesthesiology
Volume55
Issue number7
Publication statusPublished - 2006 Jul

Keywords

  • Antinociceptive effect
  • Esmolol
  • Landiolol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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