Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami; Osamu Nakagawasai; Shigeo Fujii; Masahiro Hosono; Soichi Hozumi; Akihisa Esashi; Ryoo Taniguchi; Tadashi Okamura; Takashi Suzuki; Hironobu Sasano; Teruyuki Yanagisawa; Koichi Tan-No; Takeshi Tadano; Kenji Kitamura; Kensuke Kisara

doi:10.1016/S0006-8993(00)02295-2

Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami, Osamu Nakagawasai, Shigeo Fujii, Masahiro Hosono, Soichi Hozumi, Akihisa Esashi, Ryoo Taniguchi, Tadashi Okamura, Takashi Suzuki, Hironobu Sasano, Teruyuki Yanagisawa, Koichi Tan-No, Takeshi Tadano, Kenji Kitamura, Kensuke Kisara

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	123-127
Number of pages	5
Journal	Brain research
Volume	868
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(00)02295-2
Publication status	Published - 2000 Jun 16

Keywords

Calcium channel
Cilnidipine
Nociception

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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Murakami, M., Nakagawasai, O., Fujii, S., Hosono, M., Hozumi, S., Esashi, A., Taniguchi, R., Okamura, T., Suzuki, T., Sasano, H., Yanagisawa, T., Tan-No, K., Tadano, T., Kitamura, K., & Kisara, K. (2000). Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. Brain research, 868(1), 123-127. https://doi.org/10.1016/S0006-8993(00)02295-2

Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. / Murakami, Manabu; Nakagawasai, Osamu; Fujii, Shigeo; Hosono, Masahiro; Hozumi, Soichi; Esashi, Akihisa; Taniguchi, Ryoo; Okamura, Tadashi; Suzuki, Takashi ; Sasano, Hironobu; Yanagisawa, Teruyuki; Tan-No, Koichi; Tadano, Takeshi; Kitamura, Kenji; Kisara, Kensuke.

In: Brain research, Vol. 868, No. 1, 16.06.2000, p. 123-127.

Research output: Contribution to journal › Article

Murakami, Manabu ; Nakagawasai, Osamu ; Fujii, Shigeo ; Hosono, Masahiro ; Hozumi, Soichi ; Esashi, Akihisa ; Taniguchi, Ryoo ; Okamura, Tadashi ; Suzuki, Takashi ; Sasano, Hironobu ; Yanagisawa, Teruyuki ; Tan-No, Koichi ; Tadano, Takeshi ; Kitamura, Kenji ; Kisara, Kensuke. / Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. In: Brain research. 2000 ; Vol. 868, No. 1. pp. 123-127.

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