TY - JOUR
T1 - Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist
AU - Murakami, Manabu
AU - Nakagawasai, Osamu
AU - Fujii, Shigeo
AU - Hosono, Masahiro
AU - Hozumi, Soichi
AU - Esashi, Akihisa
AU - Taniguchi, Ryoo
AU - Okamura, Tadashi
AU - Suzuki, Takashi
AU - Sasano, Hironobu
AU - Yanagisawa, Teruyuki
AU - Tan-No, Koichi
AU - Tadano, Takeshi
AU - Kitamura, Kenji
AU - Kisara, Kensuke
N1 - Funding Information:
We thank Mrs. Tetsuko Sueta and Mrs. Agnieszka Murakami for technical assistance, We also thank Dr. Kazuo Nunoki and Mr. Brant Bell for critically reading the manuscript. We also thank Boehringer Ingelheim Co. for their help. This research was supported by grants-in-aid from the Ministry of Education, Science and Culture.
PY - 2000/6/16
Y1 - 2000/6/16
N2 - We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.
AB - We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.
KW - Calcium channel
KW - Cilnidipine
KW - Nociception
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U2 - 10.1016/S0006-8993(00)02295-2
DO - 10.1016/S0006-8993(00)02295-2
M3 - Article
C2 - 10841896
AN - SCOPUS:0034674397
VL - 868
SP - 123
EP - 127
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -