Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami; Osamu Nakagawasai; Shigeo Fujii; Masahiro Hosono; Soichi Hozumi; Akihisa Esashi; Ryoo Taniguchi; Tadashi Okamura; Takashi Suzuki; Hironobu Sasano; Teruyuki Yanagisawa; Koichi Tan-No; Takeshi Tadano; Kenji Kitamura; Kensuke Kisara

doi:10.1016/S0006-8993(00)02295-2

Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami, Osamu Nakagawasai, Shigeo Fujii, Masahiro Hosono, Soichi Hozumi, Akihisa Esashi, Ryoo Taniguchi, Tadashi Okamura, Takashi Suzuki, Hironobu Sasano, Teruyuki Yanagisawa, Koichi Tan-No, Takeshi Tadano, Kenji Kitamura, Kensuke Kisara

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	123-127
Number of pages	5
Journal	Brain research
Volume	868
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(00)02295-2
Publication status	Published - 2000 Jun 16

Keywords

Calcium channel
Cilnidipine
Nociception

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02295-2

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Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. / Murakami, Manabu; Nakagawasai, Osamu; Fujii, Shigeo; Hosono, Masahiro; Hozumi, Soichi; Esashi, Akihisa; Taniguchi, Ryoo; Okamura, Tadashi; Suzuki, Takashi ; Sasano, Hironobu; Yanagisawa, Teruyuki; Tan-No, Koichi; Tadano, Takeshi; Kitamura, Kenji; Kisara, Kensuke.

In: Brain research, Vol. 868, No. 1, 16.06.2000, p. 123-127.

Research output: Contribution to journal › Article › peer-review

Murakami, Manabu ; Nakagawasai, Osamu ; Fujii, Shigeo ; Hosono, Masahiro ; Hozumi, Soichi ; Esashi, Akihisa ; Taniguchi, Ryoo ; Okamura, Tadashi ; Suzuki, Takashi ; Sasano, Hironobu ; Yanagisawa, Teruyuki ; Tan-No, Koichi ; Tadano, Takeshi ; Kitamura, Kenji ; Kisara, Kensuke. / Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. In: Brain research. 2000 ; Vol. 868, No. 1. pp. 123-127.

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abstract = "We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.",

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author = "Manabu Murakami and Osamu Nakagawasai and Shigeo Fujii and Masahiro Hosono and Soichi Hozumi and Akihisa Esashi and Ryoo Taniguchi and Tadashi Okamura and Takashi Suzuki and Hironobu Sasano and Teruyuki Yanagisawa and Koichi Tan-No and Takeshi Tadano and Kenji Kitamura and Kensuke Kisara",

note = "Funding Information: We thank Mrs. Tetsuko Sueta and Mrs. Agnieszka Murakami for technical assistance, We also thank Dr. Kazuo Nunoki and Mr. Brant Bell for critically reading the manuscript. We also thank Boehringer Ingelheim Co. for their help. This research was supported by grants-in-aid from the Ministry of Education, Science and Culture.",

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AU - Murakami, Manabu

AU - Nakagawasai, Osamu

AU - Fujii, Shigeo

AU - Hosono, Masahiro

AU - Hozumi, Soichi

AU - Esashi, Akihisa

AU - Taniguchi, Ryoo

AU - Okamura, Tadashi

AU - Suzuki, Takashi

AU - Sasano, Hironobu

AU - Yanagisawa, Teruyuki

AU - Tan-No, Koichi

AU - Tadano, Takeshi

AU - Kitamura, Kenji

AU - Kisara, Kensuke

N1 - Funding Information: We thank Mrs. Tetsuko Sueta and Mrs. Agnieszka Murakami for technical assistance, We also thank Dr. Kazuo Nunoki and Mr. Brant Bell for critically reading the manuscript. We also thank Boehringer Ingelheim Co. for their help. This research was supported by grants-in-aid from the Ministry of Education, Science and Culture.

PY - 2000/6/16

Y1 - 2000/6/16

N2 - We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

AB - We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

KW - Calcium channel

KW - Cilnidipine

KW - Nociception

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Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

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Keywords

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