Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami, Osamu Nakagawasai, Shigeo Fujii, Masahiro Hosono, Soichi Hozumi, Akihisa Esashi, Ryoo Taniguchi, Tadashi Okamura, Takashi Suzuki, Hironobu Sasano, Teruyuki Yanagisawa, Koichi Tan-No, Takeshi Tadano, Kenji Kitamura, Kensuke Kisara

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalBrain research
Volume868
Issue number1
DOIs
Publication statusPublished - 2000 Jun 16

Keywords

  • Calcium channel
  • Cilnidipine
  • Nociception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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