TY - JOUR
T1 - Antimicrobial susceptibility of respiratory tract pathogens in Japan during PROTEKT years 1-3 (1999-2002)
AU - Inoue, Matsuhisa
AU - Kaneko, Kenichi
AU - Akizawa, Kouji
AU - Fujita, Shinichi
AU - Kaku, Mitsuo
AU - Igari, Jun
AU - Yamaguchi, Keizo
AU - Kohno, Shigeru
AU - Yamanaka, Kiyoharu
AU - Iinuma, Yoshitsugu
AU - Murase, Mitsuharu
AU - Yokoyama, Takashi
AU - Asari, Seishi
AU - Hirakata, Yoichi
PY - 2006/2
Y1 - 2006/2
N2 - Data are presented on antimicrobial resistance among isolates of Streptococcus pneumoniae, Streptoco-ccus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis collected in Japan during years 1-3 (1999-2002) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin (PROTEKT) surveillance study. In addition to the standard panel of PROTEKT antimicrobial agents, eight other agents often used in Japan also were tested against these isolates. The majority (30%-55%) of S. pneumoniae and H. influenzae isolates were collected from patients with community-acquired pneumonia, whereas most (>70%) S. pyogenes isolates came from patients with tonsillitis/pharyngitis. Penicillin and macrolide resistance were high among isolates of S. pneumoniae, averaging 30.9%-44.5% and 77.2%-79.9%, respectively, across all centers over the 3 study years; the highest occurrences were reported among pediatric patients aged 0-2 years. The erm(B) genotype accounted for >50% of all erythromycin-resistant isolates each study year. S. pyogenes isolates were highly susceptible to most antimicrobial agents except the macrolides and tetracycline. β-Lactamase production among H. influenzae isolates range was 8.5%-9.7% per annum. A total of 9 β-lactamase-negative, ampicillin-resistant isolates were collected during the study. Almost all (>95%) M. catarrhalis isolates were β-lactamase positive each year. Telithromycin was highly active against all pathogens examined in this study during all 3 years.
AB - Data are presented on antimicrobial resistance among isolates of Streptococcus pneumoniae, Streptoco-ccus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis collected in Japan during years 1-3 (1999-2002) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin (PROTEKT) surveillance study. In addition to the standard panel of PROTEKT antimicrobial agents, eight other agents often used in Japan also were tested against these isolates. The majority (30%-55%) of S. pneumoniae and H. influenzae isolates were collected from patients with community-acquired pneumonia, whereas most (>70%) S. pyogenes isolates came from patients with tonsillitis/pharyngitis. Penicillin and macrolide resistance were high among isolates of S. pneumoniae, averaging 30.9%-44.5% and 77.2%-79.9%, respectively, across all centers over the 3 study years; the highest occurrences were reported among pediatric patients aged 0-2 years. The erm(B) genotype accounted for >50% of all erythromycin-resistant isolates each study year. S. pyogenes isolates were highly susceptible to most antimicrobial agents except the macrolides and tetracycline. β-Lactamase production among H. influenzae isolates range was 8.5%-9.7% per annum. A total of 9 β-lactamase-negative, ampicillin-resistant isolates were collected during the study. Almost all (>95%) M. catarrhalis isolates were β-lactamase positive each year. Telithromycin was highly active against all pathogens examined in this study during all 3 years.
KW - Antimicrobial susceptibility
KW - Haemophilus influenzae
KW - Moraxella catarrhalis
KW - Streptococcus pneumoniae
KW - Streptococcus pyogenes
KW - Telithromycin
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U2 - 10.1007/s10156-005-0421-z
DO - 10.1007/s10156-005-0421-z
M3 - Article
C2 - 16506084
AN - SCOPUS:33644603390
VL - 12
SP - 9
EP - 21
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 1
ER -