TY - JOUR
T1 - Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2004
AU - Yoshida, Isamu
AU - Fujimura, Takaji
AU - Itoh, Yoshihisa
AU - Tachibana, Mineji
AU - Kaku, Mitsuo
AU - Kanemitsu, Keiji
AU - Takahashi, Choichiro
AU - Shiotani, Joji
AU - Ono, Yuka
AU - Baba, Hisashi
AU - Matsuo, Shuji
AU - Asari, Seishi
AU - Matsuoka, Kimiko
AU - Kusano, Nobuchika
AU - Nose, Motoko
AU - Saikawa, Tetsunori
AU - Hiramatsu, Kazufumi
AU - Kohno, Shigeru
AU - Hirakata, Yoichi
AU - Yamane, Nobuhisa
AU - Nakasone, Isamu
AU - Yamano, Yoshinori
PY - 2008/9
Y1 - 2008/9
N2 - We determined MICs of antibacterial agents against 1,248 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2004. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Antibacterial susceptibility of Enterobacteriaceae to most β-lactams was comparable to that described in our previous report on isolates in 2002. Strains producing extended-spectrum β-lactamases(ESBL) accounted for 2.5% of Escherichia coli, 0% of Klebsiella spp., and 9.2% of Proteus spp. Notably, 16.7% of Proteus mirabilis was found to produce ESBL. Most antibacterial agents showed good activity against Moraxella catarrhalis. Among Haemophilus influenzae, 9.3% produced β-lactamase and 57.7% were β-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents-tobramycin, doripenem, and amikacin-showed an MIC90 of ≤8 μg/mL. Of all P. aeruginosa strains, 8.9% were resistant to seven or more agents of ten antipseudomonal agents, a decrease compared to results reported in 2002. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2002.
AB - We determined MICs of antibacterial agents against 1,248 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2004. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Antibacterial susceptibility of Enterobacteriaceae to most β-lactams was comparable to that described in our previous report on isolates in 2002. Strains producing extended-spectrum β-lactamases(ESBL) accounted for 2.5% of Escherichia coli, 0% of Klebsiella spp., and 9.2% of Proteus spp. Notably, 16.7% of Proteus mirabilis was found to produce ESBL. Most antibacterial agents showed good activity against Moraxella catarrhalis. Among Haemophilus influenzae, 9.3% produced β-lactamase and 57.7% were β-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents-tobramycin, doripenem, and amikacin-showed an MIC90 of ≤8 μg/mL. Of all P. aeruginosa strains, 8.9% were resistant to seven or more agents of ten antipseudomonal agents, a decrease compared to results reported in 2002. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2002.
KW - Clinical isolate
KW - Drug susceptibility
KW - Gram-negative bacteria
KW - Multidrug-resistant pseudomonas aeruginosa
KW - Surveillance
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M3 - Article
AN - SCOPUS:67650712927
VL - 56
SP - 562
EP - 579
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 5
ER -