Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices

Shigeru Fujimura, Tetsuro Sato, Sachiko Hayakawa, Masato Kawamura, Emiko Furukawa, Akira Watanabe

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    In vitro efficacy of combined eradication therapy with clarithromycin and daptomycin against biofilm-formed methicillin-resistant Staphylococcus aureus on the orthopedic titanium devices was evaluated. The bactericidal effect of this antibiotic was investigated by a re-culture test, the scanning electron microscopy, and fluorescence microscopy using a double-staining dyes. Clarithromycin decreased the amount to half in 24 h. Although MRSA biofilms were not eradicated with clarithromycin or daptomycin alone, clarithromycin combined with daptomycin was useful to sterilize titanium devices within 72 h. This in vitro study showed that combined treatment with clarithromycin plus daptomycin is useful to eradicate staphylococcal biofilms formed on orthopedic devices.

    Original languageEnglish
    Pages (from-to)756-759
    Number of pages4
    JournalJournal of Infection and Chemotherapy
    Volume21
    Issue number10
    DOIs
    Publication statusPublished - 2015 Oct 1

    Keywords

    • Biofilms
    • Clarithromycin
    • Combination treatment
    • Daptomycin
    • MRSA

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Pharmacology (medical)
    • Infectious Diseases

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