Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai, Michihisa Hirata, Hiroshi Isogai, Kouki Matsuo, Satoshi Watarai, Hiroko Miura, Keiji Oguma

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalJournal of Applied Research
Volume4
Issue number1
Publication statusPublished - 2004

Keywords

  • Antimicrobial effect
  • CAP18
  • LPS
  • Leptospira

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Isogai, E., Hirata, M., Isogai, H., Matsuo, K., Watarai, S., Miura, H., & Oguma, K. (2004). Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira. Journal of Applied Research, 4(1), 180-185.