Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai; Michihisa Hirata; Hiroshi Isogai; Kouki Matsuo; Satoshi Watarai; Hiroko Miura; Keiji Oguma

Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai, Michihisa Hirata, Hiroshi Isogai, Kouki Matsuo, Satoshi Watarai, Hiroko Miura, Keiji Oguma

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

Original language	English
Pages (from-to)	180-185
Number of pages	6
Journal	Journal of Applied Research
Volume	4
Issue number	1
Publication status	Published - 2004

Keywords

Antimicrobial effect
CAP18
LPS
Leptospira

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira. / Isogai, Emiko; Hirata, Michihisa; Isogai, Hiroshi; Matsuo, Kouki; Watarai, Satoshi; Miura, Hiroko; Oguma, Keiji.

In: Journal of Applied Research, Vol. 4, No. 1, 2004, p. 180-185.

Research output: Contribution to journal › Article › peer-review

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AU - Isogai, Emiko

AU - Hirata, Michihisa

AU - Isogai, Hiroshi

AU - Matsuo, Kouki

AU - Watarai, Satoshi

AU - Miura, Hiroko

AU - Oguma, Keiji

PY - 2004

Y1 - 2004

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AB - Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

KW - Antimicrobial effect

KW - CAP18

KW - LPS

KW - Leptospira

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ER -

Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Abstract

Keywords

ASJC Scopus subject areas

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