Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai; Michihisa Hirata; Hiroshi Isogai; Kouki Matsuo; Satoshi Watarai; Hiroko Miura; Keiji Oguma

Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai, Michihisa Hirata, Hiroshi Isogai, Kouki Matsuo, Satoshi Watarai, Hiroko Miura, Keiji Oguma

Research output: Contribution to journal › Article › peer-review

Abstract

Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

Original language	English
Pages (from-to)	180-185
Number of pages	6
Journal	Journal of Applied Research
Volume	4
Issue number	1
Publication status	Published - 2004

Keywords

Antimicrobial effect
CAP18
LPS
Leptospira

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

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title = "Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira",

abstract = "Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.",

keywords = "Antimicrobial effect, CAP18, LPS, Leptospira",

author = "Emiko Isogai and Michihisa Hirata and Hiroshi Isogai and Kouki Matsuo and Satoshi Watarai and Hiroko Miura and Keiji Oguma",

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T1 - Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

AU - Isogai, Emiko

AU - Hirata, Michihisa

AU - Isogai, Hiroshi

AU - Matsuo, Kouki

AU - Watarai, Satoshi

AU - Miura, Hiroko

AU - Oguma, Keiji

PY - 2004

Y1 - 2004

N2 - Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

AB - Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

KW - Antimicrobial effect

KW - CAP18

KW - LPS

KW - Leptospira

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M3 - Article

AN - SCOPUS:6444234288

VL - 4

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EP - 185

JO - Journal of Applied Research

JF - Journal of Applied Research

SN - 1537-064X

IS - 1

ER -

Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Abstract

Keywords

ASJC Scopus subject areas

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