Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.
|Number of pages||6|
|Journal||Journal of Applied Research|
|Publication status||Published - 2004|
- Antimicrobial effect
ASJC Scopus subject areas
- Pharmacology (medical)