Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai, Michihisa Hirata, Hiroshi Isogai, Kouki Matsuo, Satoshi Watarai, Hiroko Miura, Keiji Oguma

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

    Original languageEnglish
    Pages (from-to)180-185
    Number of pages6
    JournalJournal of Applied Research
    Volume4
    Issue number1
    Publication statusPublished - 2004

    Keywords

    • Antimicrobial effect
    • CAP18
    • LPS
    • Leptospira

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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