Abstract
Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.
Original language | English |
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Pages (from-to) | 180-185 |
Number of pages | 6 |
Journal | Journal of Applied Research |
Volume | 4 |
Issue number | 1 |
Publication status | Published - 2004 |
Keywords
- Antimicrobial effect
- CAP18
- LPS
- Leptospira
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)